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. Author manuscript; available in PMC: 2018 Jul 31.
Published in final edited form as: AIDS. 2017 Jul 31;31(12):1669–1678. doi: 10.1097/QAD.0000000000001554

Table 1. Multivariable Regression Analysis of Drug Transporter Expression Methods on TPR.

Forward stepwise regression was performed using TPR for each drug as the dependent variable, with plasma concentration and efflux transporter expression as independent variables for the all methods used. Only the variables that were found to be significant in the univariate analysis were included. P values for each independent variable are shown in the table, with statistically significant variables bolded. R2 values for each regression model are shown on the far right. Models that did not identify any of the included variables as statistically significant in the univariate analysis do not have R2 values and are shown as “n/a”

Drug Method MDR1 BCRP MRP2 MRP1 MRP4 R2
TFV qPCR - - 0.01 - - 0.09
WB - 0.01 - 0.05 - 0.38
QTAP - 0.01 - - - 0.11
IHC - - - - - n/a
FTC qPCR - 0.007 - 0.008 - 0.41
WB - 0.01 - 0.002 - 0.51
QTAP 0.04 - 0.05 - - 0.15
IHC - - - - - n/a
RAL qPCR 0.56 0.002 - 0.002 - 0.43
WB - 0.03 - 0.01 - 0.51
QTAP - - - 0.58 0.008 0.16
IHC - - - - - n/a
EFV qPCR - 0.004 - 0.07 - 0.39
WB - 0.12 - - - 0.22
QTAP - - - - - n/a
IHC - - - - - n/a
ATZ qPCR - - - - 0.06 0.17
WB - - - - - n/a
QTAP - - - - - n/a
IHC - - - - - n/a
MVC qPCR - - - 0.002 - 0.23
WB - - - - - n/a
QTAP - - - - - n/a
IHC - - - - - n/a