Correction: Whole-Genome Saliva and Blood DNA Methylation Profiling in Individuals with a Respiratory Allergy

There is a typographical error in Table 2. Table 2 reports averaged values of multiple CpG sites in the reported gene regions instead of the average of the single CpG site corresponding to the validated cg-probes. For instance, for cg19754622 in the STK32C gene region (S1 Dataset), the authors reported the average of the 6 CpG sites that were analyzed along with the CpG-site of interest (cg19754622 = CpG1). A similar switch of data for the other two gene regions is also present.

Table 2. Comparison of methylation differences between RA cases and controls in PBMC and saliva as assessed by Illumina 450K bead chips and bisulfite pyrosequencing.

Assay	cg-probe	gene	Blood PBMC			Saliva
			Mean β (%) ±SD		Δβ (%)	Mean β (%) ±SD		Δβ (%)
			RA cases	Controls		RA cases	Controls
450K1	cg19754622	STK32C	52.39 ± 5.3	72.17 ± 21.0	-19.78*	30.62 ± 13.0	64.82 ± 28.5	-34.21*
	cg08899523	FGFR2	45.15 ± 10.5	58.47 ± 9.5	-13.32*	39.52 ± 15.2	59.81 ± 9.5	-20.30*
	cg11965913	PM20D1	55.24 ± 36.6	18.65 ± 17.6	36.58*	62.63 ± 33.7	21.69 ± 20.4	40.94*
pyroseq.2	cg19754622	STK32C	52.00 ± 9.8	72.00 ± 18.6	-20.00	25.20 ± 14.6	61.20 ± 27.8	-36.00*
	cg08899523	FGFR2	39.80 ± 9.0	53.27 ± 11.4	-13.47	31.20 ± 14.9	51.60 ± 13.2	-20.40^
	cg11965913	PM20D1	59.00 ± 32.6	25.20 ± 24.3	33.80	64.70 ± 33.9	24.80 ± 21.5	39.90*

Statistics were performed: ¹using M-values with Limma package, or ²Mann-Witney U test to study differences between RA cases and controls (*P≤0.05; ^P<0.1).

The statistical analyses were performed with the correct values, so this error does not affect the results or conclusions of this study. Please see the corrected Table 2 here.

Supporting information

S1 Dataset. Pyrosequencing Data.

(XLSX)