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. 2008 Feb 7;23(5):307. doi: 10.1007/s12264-007-0046-6

Roles of NF-κB in central nervous system damage and repair

NF-κB 在中枢神经系统损伤和修复中的作用

Li Yang 1, Lu-Yang Tao 1, Xi-Ping Chen 1,✉
PMCID: PMC5550580  PMID: 17952141

Abstract

NF-κB family is a kind of nuclear factors in B lymphocyte that can bind to the immunoglobulin κ-chain enhancer and enhance transcriptional activity. NF-κB/Rel proteins, as a dimeric transcription factor, control the expression of genes that regulate a broad range of biological processes through canonical and non-canonical pathways. In the central nervous system, NF-κB controls inflammatory reactions and the apoptotic cell death following nerve injury. It also contributes to the infarction and cell death in stroke models and patients. However, NF-κB is essential for neurosurvival as well. NF-κB activation is a part of recovery process that may protect neurons against oxidative-stresses or brain ischemia-induced apoptosis and neurodegeneration. Inhibition of NF-κB may reduce its neuroprotection activity. Hence the dual opposite effects of NF-κB on cells. The ultimate survival or death of neurons depends on which, where and when the NF-κB factors are activated.

Keywords: NF-κB, central nervous system, injury, repair

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