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. 2010 Aug 6;26(4):322–326. doi: 10.1007/s12264-010-0301-0

Lack of association between ADRA2B -4825 gene insertion/deletion polymorphism and migraine in Chinese Han population

中国汉族人群ADRA2B 基因-4825 插入/缺失多态与偏头痛易感性无关

Jian-Qiang Ni 1,2, Sha-Sha Jia 2, Min Liu 3, Shou-Gong Chen 1, Yu-Ting Jiang 1, Wan-Li Dong 2,✉, Yu-Zhen Gao 1,✉
PMCID: PMC5552571  PMID: 20651814

Abstract

Objective

The present study aimed to estimate the association between susceptibility to migraine and the 12-nucleotide insertion/deletion (indel) polymorphism in promoter region of α2B-adrenergic receptor gene (ADRA2B).

Methods

A case-control study was carried out in Chinese Han population, including 368 cases of migraine and 517 controls. Genomic DNA was extracted from blood samples, and DNA fragments containing the site of polymorphism were amplified by PCR. Data were adjusted for sex, age, migraine history and family history, and analyzed using a logistic regression model.

Results

There was no association between indel polymorphism and migraine, at either the allele or the genotype level.

Conclusion

These findings do not support a functional significance of ADRA2B indel polymorphism at position -4825 relative to the start codon in the far upstream region of the promoter in the present migraine subjects.

Keywords: migraine, promoter of α2B-adrenergic receptor gene, insertion/deletion polymorphism, genetic association

Footnotes

These authors contributed equally to this work.

Contributor Information

Wan-Li Dong, Phone: +86-512-66332759, Email: dwlsz@163.com.

Yu-Zhen Gao, Phone: +86-512-65880109, Email: yuzhengao@suda.edu.cn.

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