Figure 6.

Genes involved in cholesterol synthesis are upregulated upon Leishmania mexicana amastigotes infection. Relative mRNA level changes between infected and uninfected bone marrow‐derived macrophages of genes regulated by SREBP. A value of 1 corresponds to no change in gene expression. Dotted lines show either twofold up‐ or downregulation. Fdps, farnesyl diphosphate synthase; Hmgcr, 3‐hydroxy‐3‐methylglutaryl‐CoA reductase; Ldlr, low‐density lipoprotein receptor; Scd1, stearoyl‐Coenzyme A desaturase 1, Sqle: squalene epoxidase