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. 1983;2(9):1531–1535. doi: 10.1002/j.1460-2075.1983.tb01619.x

Torsional stress induces left-handed helical stretches in DNA of natural base sequence: circular dichroism and antibody binding.

E Di Capua 1, A Stasiak 1, T Koller 1, S Brahms 1, R Thomae 1, F M Pohl 1
PMCID: PMC555318  PMID: 11892807

Abstract

Above a threshold of torsional stress, the c.d. spectrum of covalently closed circular DNA of natural base sequence acquires a Z-like contribution and antibodies raised against Z-DNA are bound. Mapping of the antibody binding sites by electron microscopy reveals sites which correlate with stretches enriched in alternating purine-pyrimidine sequences and GC base pairs.

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Selected References

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