Table 1.
Secondary endpoints
| Endpoint | Time frame | Detailed description |
|---|---|---|
| Circulatory failure | 28 days | Hypotension – MAP < 65 mmHg |
| Severe cardiac arrhythmia – 40/min < HR > 150/min | ||
| ScvO2 < 70% | ||
| dCO2 > 7 mmHg | ||
| Serum lactate > 2 mmol/L | ||
| Severe metabolic acidosis (actual bicarbonate < 18 mmol/L) | ||
| Acute coronary syndrome | ||
| Acute left ventricular failure | ||
| Pulmonary embolism | ||
| Cardiac arrest | ||
| Gastrointestinal dysfunction | 28 days | Constipation |
| Ileus | ||
| Anastomotic leakage | ||
| Reoperation | ||
| Disorders of liver function | ||
| Renal dysfunction | 28 days | RIFLE criteria |
| Hematologic and coagulation disorders | 28 days | Severe bleeding |
| Coagulopathy – INR > 1.5 | ||
| Infection | 28 days | Any infection except from pneumonia |
MAP mean arterial pressure, HR heart rate, ScvO 2 central venous oxygen saturation, dCO 2 central venous-to-arterial carbon dioxide gap, INR International Normalized Ratio