Characteristics of Chronic Obstructive Pulmonary Disease (COPD) Patients Reporting Alpha-1 Antitrypsin Deficiency in the WebMD Lung Health Check Database

Abstract

Objectives: This study compared characteristics of chronic obstructive pulmonary disease (COPD) among patients with and without alpha-1 antitrypsin deficiency (A1AD).

Methods: Data from WebMD’s Lung Disease Health Check was analyzed for participants who self-reported a COPD diagnosis (N=177,865) and whether or not they had an A1AD diagnosis (based on a positive response to the question “Do you have alpha-1 antitrypsin deficiency?”). We used regression modeling to determine the relation between A1AD status and demographic characteristics, symptoms, lung function, quality of life, comorbidities, and smoking habits.

Results: Out of 177,865 participants who reported a COPD diagnosis, 1,619 (0.92%) also reported an A1AD diagnosis. When compared to the total COPD population, those with A1AD were less likely to be female (odds ratio [OR]=0.68, 95% confidence interval [CI] 0.61, 0.75) or current smokers (OR 0.72, 95% CI 0.62, 0.83), and more likely to know their lung function value (OR=3.44, 95% CI 3.07, 3.87). With regard to symptoms, those with A1AD were less likely to report wheezing (OR=0.82, 95% CI 0.75, 0.91) and chronic cough (OR=0.81, 95% CI 0.73, 0.89) and more likely to report tightness in the chest (OR= 1.19, 95% CI 1.08, 1.32). Overall, A1AD participants had a lower quality of life with a higher proportion reporting severe impairment in work life (OR=1.55, 95% CI 1.39, 1.7), home life (OR=1.40, 95% CI 1.26, 1.56), and personal relationships (OR=1.48, 95% CI 1.32, 1.65).

Conclusions: COPD patients with A1AD report significantly worse quality of life relative to the non-A1AD COPD population.

Introduction

Alpha-1 antitrypsin deficiency (A1AD) is the major known genetic cause of chronic obstructive pulmonary disease (COPD) and accounts for 1%-2% of prevalent COPD cases.^1-5 Alpha-1 antitrypsin, a serine protease inhibitor (SERPIN) produced mainly by the liver, protects the elastin of the alveoli from damage caused by the body’s own neutrophil elastase.^6,7 In the most severe deficient (Z) type of A1AD, alpha-1 antitrypsin is misfolded and becomes trapped in the liver. This leads to a reduction in the concentrations of alpha-1 antitrypsin in the plasma and tissues which results in an increased risk of emphysema and cirrhosis and fibrosis of the liver.^1,7-11 Cigarette smoke can compound the problem as it stimulates neutrophil influx into the lungs and can result in oxidative inactivation of the alpha-1 antitrypsin present in lung tissue. This leads to early-onset lung disease in patients with A1AD, with evidence of disease occurring years earlier than in non-smokers with A1AD or smokers without A1AD.^3,8,12-14 Most A1AD patients who develop pulmonary disease begin experiencing symptoms between the ages of 20 and 50, with diagnosis typically occurring in their mid-forties, often with a gap of many years from symptom onset to diagnosis.^8,15-17 Life expectancy for A1AD patients is greatly reduced after the onset of symptoms.¹⁸

In the United States, there are an estimated 10 million genetic carriers of A1AD, and an estimated 60,000 to 100,000 people with severe A1AD (most commonly PI ZZ subtype), yet there are fewer than 10,000 on augmentation therapy, suggesting that the majority of individuals with severe A1AD are undiagnosed.^12,19-21 Current recommendations are that all patients with COPD should be tested for A1AD.^2,17,22

Analyzing some of the differences between COPD patients with and without A1AD may be important to better understanding the A1AD population. These differences can potentially be used to better target detection and treatment efforts. This analysis uses a very large contemporary dataset to examine how COPD patients reporting A1AD differ with regard to demographic characteristics, symptoms, lung function, quality of life, comorbidities, and smoking habits from COPD patients not reporting A1AD (i.e., A1AD-replete COPD patients).

Methods

WebMD, a website providing reliable health care information to the public, is visited by an estimated 95% of adults searching the web for health-related information.²³ WebMD receives over 40,000 inquiries each month related to lung health issues.²³

The COPD Foundation and WebMD collaborated in 2009 to release the Lung Disease Health Check, an online survey. The Lung Disease Health Check asks participants a wide range of questions regarding COPD and lung health. People searching WebMD for lung health-related questions were given the option to participate in the survey and over 600,000 people responded between 2009 and 2013. The self-report survey poses a wide variety of questions, including demographics, symptoms, comorbidities, pulmonary function, diagnosis, possible causes and smoking habits, quality of life and mental health, beliefs about lung health, treatment and hospitalizations, and exercise and activity. A COPD diagnosis was established with a positive response to the question “Have you been diagnosed with COPD? or “Have you been diagnosed with emphysema? and A1AD was established with a positive response to the question “Do you have alpha-1 antitrypsin deficiency?”

This cross-sectional study uses data from the Lung Disease Health Check from 2009-2012. All participants reporting a COPD diagnosis were included in this study with the exception of those with missing values for age or gender (N=177,820); more than 400,000 respondents of the survey did not report a COPD diagnosis and were excluded. To be included in the study, respondents had to be at least 18 years of age. Participants reporting a COPD diagnosis were then divided into 2 groups, those reporting A1AD (N=1,619) and those not reporting A1AD (N=176,191).

Smoking status was divided into 3 categories: never smokers, former smokers, and current smokers. Participants were asked about pulmonary symptoms, which included shortness of breath, chronic cough, tightness in the chest, and wheezing. Comorbidities included heartburn, sinus infections, joint pain and swelling, diabetes, heart disease, hypertension, depression, and osteoporosis. Lung comorbidities included asthma, bronchiolitis obliterans, pulmonary fibrosis, sarcoidosis, and pulmonary hypertension.

Participants were asked about a variety of factors that they believed may have contributed to their lung disease; of those, smoking and genetic factors were considered in this study. Participants were asked about the number of times they felt they were short of breath in the previous 2 weeks and how many times they had been admitted to a hospital with lung-related health issues. They were also asked how many days of work or school they had been absent in the past year due to their lungs.

Participants were asked to rank quality of life impairment in 3 areas: work life, home life, and personal relationships. Quality of life impairment was ranked in categories of no impairment, mild impairment, moderate impairment, and severe impairment. This study also included how participants felt emotionally about their lung health issues. Participants could report their feelings as they became fearful when symptoms occurred, worried about how long they had left to live, angry for putting their loved ones through the situation, grieving for the person they used to be, and/or they had accepted their condition and were trying to take good care of themselves.

All variables in this study were categorical. All statistical analyses were performed using SAS version 9.3 (SAS Institute Inc. Cary, NC). All variables in both the A1AD and non-A1AD groups were analyzed by the frequency procedure and chi-square test. In all frequency procedures and chi-square tests, the number included was 177,820 with the exception of the forced expiratory in 1 second (FEV₁) score variable which was created from those who knew their FEV₁ score.

Both univariate and multivariate regressions were performed on each dependent variable. All multivariate regression models were adjusted for age, gender, and smoking status, with the exception of the model analyzing if patients believed that smoking contributed to their disease, which was adjusted for gender and age only.

Results

Of respondents who reported a COPD diagnosis, 0.92% (1,619/177,865) also reported having A1AD. Respondents who had A1AD were less likely to be current smokers than respondents who had non-A1AD COPD, although most measures of severity were worse in those with A1AD. Frequencies and p-values can be found in Tables 1 and 2.

Table 3 shows a multivariate logistic regression model predicting A1AD status. Alpha-1 antitrypsin deficiency patients were less likely to be current smokers (odds ratio [OR] 0.72, 95% confidence interval [CI] 0.62, 0.83). COPD patients with A1AD were also more likely to be younger than non-A1AD COPD patients (OR 3.44, 95% CI 2.71, 4.37 for 18-24 year olds, OR 1.97, 95% CI 1.57, 2.47 for 25-34 year olds). COPD patients with A1AD were also less likely to be female (OR=0.68, 95% CI 0.61, 0.75) than non-A1AD COPD patients.

Respondents with A1AD were more likely to know their FEV₁ values (OR=3.44, 95% CI 3.07, 3.87, Table 4), and more likely to report an FEV₁ value of less than 50% predicted (OR=1.42, 95% CI 1.12, 1.82, Table 4 and Figure 1).

COPD patients with A1AD were more likely to report chest tightness (OR=1.19, 95% CI 1.08, 1.32), but less likely to report chronic cough (OR=0.81, 95% CI 0.73, 0.89) or wheezing (OR=0.82 95% CI 0.75, 0.91, Figure 2).

The relationship between A1AD and comorbidities is depicted in Figure 3. Comorbidities significantly more common in A1AD included osteoporosis, severe asthma, bronchiolitis obliterans, pulmonary fibrosis, sarcoidosis, and pulmonary hypertension. The comorbidities less likely in A1AD included sinus infection, hypertension, and mild to moderate asthma.

COPD patients with A1AD were more likely to believe that genetics (OR=4.39, 95% CI 4.20, 5.15) had contributed to their disease and less likely to believe that smoking (OR=0.83, 95% CI 0.79, 0.96) had contributed to their disease. They also were more likely to report a hospital admission due to their lung condition (OR=1.64, 95% CI 1.48, 1.82).

The effect of A1AD status on quality of life is depicted in Figure 4. Relative to COPD patients without A1AD, those with A1AD reported more severe impairment of work life, home life, and personal relationships, in addition to more daily shortness of breath and the inability to work. Also, A1AD patients were more likely to be concerned about how long they will live (OR=1.25, 95% CI 1.13, 1.39), be angry for burdening their loved ones with their illness (OR=1.40, 95% CI 1.25, 1.58), and be grieving for the person they used to be (OR=1.26, 95% CI 1.12, 1.41, Table 5).

Discussion

This study used a novel database to compare a sample of the U.S. COPD population reporting A1AD, the major known genetic cause of COPD, to COPD patients not reporting A1AD. Slightly fewer than 1% of the COPD population reported A1AD, which is similar to other estimates of the proportion of COPD patients who have A1AD. ^1,2 We found that COPD patients with A1AD are different from patients with non-A1AD-related COPD in demographic features, smoking habits, symptoms, comorbidities, and quality of life measures.

With regard to demographics, A1AD patients were more likely to be men than non- A1AD patients (45.3% versus 37.3%). In addition, A1AD patients were younger and less likely to be current smokers (Table 1). Six percent to 10% of respondents were under the age of 35, where one would expect the prevalence of COPD to be extremely low. Exclusion of these participants from the analysis had no appreciable effect on the results (data not shown).

In keeping with the autosomal co-dominant nature of A1AD, it is of interest that there is no gender predilection demonstrated in multiple studies of individuals with A1AD, ^24,25 suggesting that testing for A1AD may be biased toward testing women with COPD or that women are more likely to visit the WebMD COPD site. These demographic findings point to true differences in the A1AD versus the non-A1AD population. For example, the socioeconomic factors that are strong predictors of COPD in the general population may be less important in the A1AD population.³

Another interesting finding was that COPD patients reporting an A1AD diagnosis were more likely to know their lung function (Table 4 and Figure 1). This suggests that those with A1AD are more aware of their disease status and may be more educated about their disease than the general COPD population. Those with A1AD were also more likely to have a lower FEV₁ value.

The analysis of comorbidities found that AIAD patients reported several comorbidities with a higher frequency. For example, A1AD patients were more likely to report osteoporosis, which has also been demonstrated in other studies of A1AD populations.²⁶ Patients with A1AD also reported more severe asthma, although this may, in part, be related to A1AD often being diagnosed with asthma for several years prior to the correct diagnosis of A1AD ³ and/or to the high prevalence of self-reported wheezing among patients with A1AD.²⁴ When mild-moderate asthma was combined with severe asthma, both the groups with and without A1AD had a similar prevalence (32.9% versus 33.2%). The overlap between asthma and COPD has become the focus of recent work, including better case definitions for what comprises asthma in a patient with COPD.^28,29 Of course, in this study, both the presence and severity of asthma was self-assessed and self-reported and not objectively validated. Interestingly, though, in this database, wheezing was less frequently reported in the A1AD population (Figure 2).

Overall, A1AD patients reported less ability to work than other COPD patients. Both Campos et al and Stoller et al have reported similar findings in work absenteeism.^16,30 This suggests more disability in A1AD patients. This is of particular concern in the A1AD population as they are younger and still of working age.

Some of the most compelling findings in this study relate to the effect of A1AD on quality of life measures. Patients with A1AD were more likely to experience severe impairment to their work lives, home lives, and in their personal relationships. These data accord with the finding that 30% of participants in the National Heart Lung and Blood Institute (NHLBI) Registry of Individuals with Severe Deficiency of Alpha-1 Antitrypsin, whose mean age was 46 years, reported being medically unemployed.²⁴ Patients with A1AD also had an increased risk of reporting more negative feelings associated with their disease. Alpha-1 antitrypsin deficiency individuals were more worried about how long they had left to live and grieved for who they used to be before they developed lung disease. Additionally, they were angry for burdening loved ones with their illness. This may reflect A1AD patients tending to have more severe lung disease at an earlier age and requiring more support from their loved ones. Also, given the genetic nature of the disease, they may be concerned about the health of their loved ones.

Other studies have also found similar associations with A1AD and poor quality of life; however, these studies typically have a small sample size or are dated.^13,16,30

This cross-sectional study may have several limitations. Given the nature of online surveys like the WebMD Lung Disease Health Check, it is difficult to know details about the source population from which the sample came. For example, we do not know the exact age (only an age within a range) nor do we know where respondents live. As this survey was available to people with access to the web and the WebMD site, it is impossible to know the survey response rate. For example, the results have very different implications if the respondent population consists of mostly patients with severe deficiency of alpha-1 antitrypsin or if respondents include PI MZ heterozygotes with milder deficiency. Notably, however, if the A1AD respondents in this survey represent an admixture of individuals with both severe and mild A1AD (e.g., PI MZ, which has been less associated with significant health consequences), then our findings further underscore the adverse consequences of having severe A1AD.

This survey was purely self-reported and could be influenced by issues related to recall bias and over/under-reporting. However, some key findings of this study are in agreement with studies based on other nationally recognized surveys and other studies in the current literature. For example, we found that about 1% of the COPD population reported A1AD ³¹ and about 60% of patients reporting COPD were women.³² Finally, because ascertainment in this study required access to the web, the features of the study population may be conditioned by better access to technology and to concomitant features (e.g., higher socioeconomic status). Method of ascertainment has been shown to affect the clinical features and prognosis of patients with A1AD.³³

This study has shown a variety of differences in A1AD and non-A1AD COPD patients. Of particular importance is the severity of quality of life impairment experienced by A1AD patients. It is important that health care providers be aware of and consider the fact that many A1AD patients have additional needs that may require attention. Such quality of life needs have infrequently been assessed in earlier A1AD studies.

Given that many physicians do not adhere to the guidelines calling for testing all COPD patients for A1AD,³³ it is important to raise awareness in the medical community that these groups of patients are, in fact, different. Therefore, case-finding guidelines should be followed. Also, clinicians should recognize the distinctive features of A1AD patients in order to provide tailored care that better meets their needs. Identification of A1AD patients will allow them to consider other therapies such as augmentation therapy ³⁴ and to be counseled on smoking avoidance or cessation.³⁵ Also, first-degree relatives (i.e., siblings, children, parents) should be tested for A1AD. Those found to also have A1AD should also receive counseling regarding smoking habits and lung health to help prevent severe lung disease at an early age.^12,34,36

While this study has limitations, it is one of the largest population-based COPD studies. Also, the sample size for the subset of A1AD patients is one of the largest reported in the literature to date. Investigations into A1AD and COPD populations will provide better insight into one of the world’s leading causes of death today.

Abbreviations

alpha-1 antitrypsin deficiency, A1AD;odds ratio,OR; confidence interval, CI; serine protease inhibitor, SERPIN; forced expiratory volume in 1 second, FEV₁; National Heart Lung and Blood Instititute, NHLBI

Funding Statement

COPD Foundation, Alpha-1 Foundation.