MTN-020 ASPIRE qualitative component: participant disposition. *IDI averaged 61 min, FGD were 159 min on average. **Reasons for single IDI women terminating product use early were (n = 34): 29, seroconversion to HIV-1; three, partner objection; two, pregnancy. Reasons for purposive selection in serial IDI (n — 19): four, lack of adherence; seven, overcoming obstacles; six, partner issues; one, trauma; one, vocal about others' non-use; two, exceptional adherer; one, chronic health issues. ***There were five seroconverters in the SIDI sample and one in the FGD sample.