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. Author manuscript; available in PMC: 2018 Jul 14.
Published in final edited form as: Pharmacology. 2017 Jul 14;100(3-4):188–193. doi: 10.1159/000478732

Fig. 2.

Fig. 2

Effect of aging and GPER on Nox-mediated contractions to GPCR agonists in renal arteries. Responses were recorded in the presence and absence of the Nox1/2-inhibitor gp91ds-tat (3 μmol/L) in young (4 months old) and aged (24 months old) wild-type and Gper−/− mice. A: Contractions to the angiotensin AT1 receptor agonist angiotensin II (Ang II, 100 nmol/L). B: Contractions to the α-adrenergic agonist phenylephrine (PE, 0.3 μmol/L). Responses are expressed as percent of contractions to KCl (60 mmol/L). Data (n=5–7 per group) are means±SEM. *p<0.05, **p<0.01 vs. untreated control (CTL); ††p<0.01 vs. wild-type; ‡‡p<0.01 vs. young.