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. 2010 Jun 3;26(3):241–246. doi: 10.1007/s12264-010-1109-7

The Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer’s disease

Gab2 信号转导通路与阿尔茨海默病

Xiao-Ling Pan 1, Ru-Jing Ren 1, Gang Wang 1,✉, Hui-Dong Tang 1, Sheng-Di Chen 1,2,✉
PMCID: PMC5560293  PMID: 20502503

Abstract

The growth factor receptor-bound protein 2 (Grb2)-associated binder (Gab) proteins are intracellular scaffolding/docking molecules, and participate in multiple signaling pathways, usually acting as the downstream effector of proteintyrosine kinases (PTKs)-triggered signal transduction pathway. When phosphorylated by PTKs, Gab proteins can recruit several signaling molecules (p85, SHP2, and Crk), and subsequently activate multiple transmitting signals that are critical for cell growth, survival, differentiation and apoptosis. Recently, it has been reported that Gab2 polymorphism is associated with the increase in the risk of Alzheimer’s disease (AD) and is involved in the pathogenesis of AD. This review mainly focuses on the structure and function of Gab2 protein and its role in the pathogenesis of AD.

关键词: Gab2 基因, 信号转导通路, 阿尔茨海默病, 载脂蛋白E

Footnotes

These authors contributed equally to this work.

Contributor Information

Gang Wang, Phone: +86-21-64457249, Email: wgneuron@hotmail.com.

Sheng-Di Chen, Email: chen_sd@medmail.com.cn.

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