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. 2010 Dec 7;26(6):455–468. doi: 10.1007/s12264-010-6023-5

Interleukin-1β with learning and memory

白介素1β 与学习和记忆

Zhen-Bo Huang 1, Guo-Qing Sheng 1,✉
PMCID: PMC5560336  PMID: 21113196

Abstract

Interleukin-1β (IL-1β) is one of the first cytokines ever described. It has long been recognized to play an important role in mediating inflammation and orchestrating the physiological and behavioral adjustments that occur during sickness. Recently, accumulating evidence has indicated that IL-1β also adversely affects cognitive function. Nevertheless, there are also some reports showing no effects or even beneficial effects of IL-1β on learning and memory. The relationship between IL-1β and cognitive impairment has not been clearly elucidated. Here we reviewed the evidence of both negative and positive effects of IL-1β on learning and memory, and the key factors that may affect the effects of IL-1β on learning and memory were discussed.

Keywords: interleukin-1β, learning, memory, dose, age, memory type, memory stage

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