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. 2010 Oct 8;26(5):411–416. doi: 10.1007/s12264-010-0625-9

The function of DNA topoisomerase IIβ in neuronal development

拓扑异构酶IIβ在神经发育中的作用

Xin Heng 1, Wei-Dong Le 1,✉
PMCID: PMC5560355  PMID: 20882068

Abstract

Type II DNA topoisomerases (Tops) are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another. In mammals, there are 2 isoforms of DNA Top II, termed Top IIα and Top IIβ. The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells. In recent years, there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division. These genes are involved in the processes of neuronal differentiation, migration, axon guidance and so on. The present review mainly focused on the research progress on the role of Top IIβ in neuronal development over the recent decades.

Keywords: neuronal development, axon guidance, neuronal differentiation

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