Table 2.
All cause mortality
|
Non-fatal myocardial infarction or death from cardiovascular disease
|
|||||
---|---|---|---|---|---|---|
Predictor | Overall | Women | Older people | Overall | Women | Older people |
Sex (male v female) | 1.19 (1.07 to 1.33) | to | 1.15 (1.03 to 1.29) | 1.11 (1.00 to 1.24) | to | 1.11 (0.99 to 1.25) |
Age: | ||||||
<45 | 1.00 | 1.00 | to | 1.00 | 1.00 | — |
45-54 | 0.96 (0.48 to 1.94) | 1.40 (0.18 to 11.24) | 0.99 (0.60 to 1.61) | 0.55 (0.19 to 1.53) | ||
55-64 | 1.58 (0.83 to 3.02) | 2.91 (0.40 to 21.37) | 1.26 (0.79 to 2.00) | 0.79 (0.31 to 2.02) | ||
65-74 | 2.57 (1.36 to 4.84) | 3.26 (0.45 to 23.59) | 1.59 (1.01 to 2.51) | 0.79 (0.32 to 1.99) | ||
≥75 | 3.57 (1.90 to 6.73) | 4.50 (0.62 to 32.50) | 1.90 (1.20 to 2.99) | 0.95 (0.38 to 2.38) | ||
Deprivation category: | ||||||
1 (least deprived) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
2 | 1.13 (0.89 to 1.43) | 0.93 (0.66 to 1.32) | 1.10 (0.86 to 1.40) | 1.14 (0.90 to 1.43 | 0.88 (0.62 to 1.24) | 1.04 (0.81 to 0.34) |
3 | 1.18 (0.95 to 1.48) | 0.92 (0.65 to 1.29) | 1.19 (0.95 to 1.50) | 1.12 (0.90 to 1.39 | 0.75 (0.53 to 1.06) | 1.06 (0.84 to 1.35) |
4 | 1.37 (1.09 to 1.72) | 1.13 (0.81 to 1.59) | 1.30 (1.03 to 1.66) | 1.24 (0.99 to 1.56 | 0.92 (0.65 to 1.30) | 1.13 (0.88 to 1.44) |
5 | 1.39 (1.09 to 1.78) | 1.03 (0.70 to 1.50) | 1.29 (1.00 to 1.68) | 1.34 (1.06 to 1.71) | 0.92 (0.63 to 1.36) | 1.15 (0.88 to 1.50) |
6 (most deprived) | 1.27 (1.01 to 1.60) | 0.97 (0.68 to 1.37) | 1.24 (0.97 to 1.58) | 1.21 (0.97 to 1.52) | 0.86 (0.60 to 1.21) | 1.12 (0.88 to 1.44) |
Statins | 0.69 (0.59 to 0.80) | 0.63 (0.49 to 0.80) | 0.72 (0.61 to 0.84) | 0.82 (0.71 to 0.95) | 0.69 (0.54 to 0.88) | 0.84 (0.71 to 0.99) |
β blockers | 0.38 (0.33 to 0.43) | 0.46 (0.37 to 0.56) | 0.39 (0.34 to 0.45) | 0.40 (0.35 to 0.46) | 0.48 (0.39 to 0.59) | 0.46 (0.40 to 0.53) |
Angiotensin converting enzyme inhibitors | 0.54 (0.48 to 0.61) | 0.55 (0.45 to 0.66) | 0.56 (0.50 to 0.64) | 0.57 (0.50 to 0.64) | 0.64 (0.53 to 0.78) | 0.61 (0.54 to 0.70) |
Nitrates | 0.68 (0.61 to 0.77) | 0.68 (0.57 to 0.82) | 0.66 (0.58 to 0.75) | 0.78 (0.69 to 0.88) | 0.78 (0.65 to 0.94) | 0.75 (0.65 to 0.85) |
Calcium blockers | 0.76 (0.67 to 0.86) | 0.74 (0.61 to 0.89) | 0.73 (0.65 to 0.83) | 0.79 (0.70 to 0.89) | 0.75 (0.62 to 0.91) | 0.76 (0.66 to 0.87) |
Antihypertensive drugs | 1.14 (1.01 to 1.29) | 0.83 (0.70 to 0.99) | 1.13 (1.00 to 1.28) | 0.90 (0.80 to 1.02) | 0.72 (0.60 to 0.86) | 0.91 (0.80 to 1.03) |
Antiplatelet drugs | 0.44 (0.39 to 0.50) | 0.49 (0.41 to 0.58) | 0.41 (0.36 to 0.47) | 0.42 (0.37 to 0.47) | 0.44 (0.37 to 0.53) | 0.39 (0.34 to 0.45) |
Warfarin | 0.97 (0.84 to 1.14) | 0.94 (0.74 to 1.20) | 0.89 (0.75-1.06) | 0.93 (0.78 to 1.10) | 0.84 (0.64 to 1.09) | 0.86 (0.71 to 1.04) |
Other covariates included in the multivariate analysis: non-steroidal anti-inflammatory drugs, disease modifying antirheumatic drugs, hormone replacement therapy, and oral contraceptives, steroids, previous cardiovascular disease, and comorbidity (diabetes, obstructive airway disease, cancer, renal failure, rheumatoid arthritis).