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. 2013 Apr 20;29(6):761–772. doi: 10.1007/s12264-013-1336-9

GluN2A versus GluN2B: twins, but quite different

Xiao-Min Zhang 1, Jian-Hong Luo 1,✉
PMCID: PMC5561830  PMID: 23604599

Abstract

N-Methyl-D-aspartate receptors (NMDARs) play vital roles in the central nervous system, as they are primary mediators of Ca2+ influx during synaptic activity. The subunits that compose NMDARs share similar topological structures but are distinct in distribution and pharmacological properties, as well as physiological and pathological functions, which make the NMDAR one of the most complex and elusive ionotropic glutamate receptors. In this review, we focus on GluN2A and GluN2B, the primary NMDAR subunits in the cortex and hippocampus, and discuss their differences in developmental expression, brain distribution, trafficking, and functional properties during neuronal activity.

Keywords: N-methyl-D-aspartate receptors, GluN2A, GluN2B, developmental expression, brain distribution, function, trafficking

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