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. 2012 Sep 12;28(5):658–666. doi: 10.1007/s12264-012-1268-9

Neuronal autophagy in cerebral ischemia

Feng Xu 1, Jin-Hua Gu 2, Zheng-Hong Qin 3,✉
PMCID: PMC5561920  PMID: 22968594

Abstract

Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components, such as long-lived proteins and organelles. In neurons, autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions, while it is upregulated in response to pathophysiological conditions, such as cerebral ischemic injury. However, the role of autophagy is more complex. It depends on age or brain maturity, region, severity of insult, and the stage of ischemia. Whether autophagy plays a beneficial or a detrimental role in cerebral ischemia depends on various pathological conditions. In this review, we elucidate the role of neuronal autophagy in cerebral ischemia.

Keywords: autophagy, cerebral ischemia, neuron, apoptosis, necrosis

Footnotes

These authors contributed equally to this work.

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