Skip to main content
PMC home page
Neuroscience Bulletin logoLink to Neuroscience Bulletin
. 2014 Oct 23;30(6):1045–1048. doi: 10.1007/s12264-014-1476-6

Connexin 30 controls the extension of astrocytic processes into the synaptic cleft through an unconventional non-channel function

Jerome Clasadonte 1,✉, Philip G Haydon 1
PMCID: PMC5562561  PMID: 25342075

The content is available as a PDF (245.2 KB).

References

  • [1].Araque A, Carmignoto G, Haydon PG, Oliet SH, Robitaille R, Volterra A. Gliotransmitters travel in time and space. Neuron. 2014;81:728–739. doi: 10.1016/j.neuron.2014.02.007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [2].Pannasch U, Rouach N. Emerging role for astroglial networks in information processing: from synapse to behavior. Trends Neurosci. 2013;36:405–417. doi: 10.1016/j.tins.2013.04.004. [DOI] [PubMed] [Google Scholar]
  • [3].Rouach N, Koulakoff A, Abudara V, Willecke K, Giaume C. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science. 2008;322:1551–1555. doi: 10.1126/science.1164022. [DOI] [PubMed] [Google Scholar]
  • [4].Pannasch U, Vargová L, Reingruber J, Ezan P, Holcman D, Giaume C, et al. Astroglial networks scale synaptic activity and plasticity. Proc Natl Acad Sci U S A. 2011;108:8467–8472. doi: 10.1073/pnas.1016650108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [5].Pannasch U, Freche D, Dallérac G, Ghézali G, Escartin C, Ezan P, et al. Connexin 30 sets synaptic strength by controlling astroglial synapse invasion. Nat Neurosci. 2014;17:549–558. doi: 10.1038/nn.3662. [DOI] [PubMed] [Google Scholar]
  • [6].Tzingounis AV, Wadiche JI. Glutamate transporters: confining runaway excitation by shaping synaptic transmission. Nat Rev Neurosci. 2007;8:935–947. doi: 10.1038/nrn2274. [DOI] [PubMed] [Google Scholar]
  • [7].Zhou JZ, Jiang JX. Gap junction and hemichannel-independent actions of connexins on cell and tissue functions—an update. FEBS Lett. 2014;588:1186–1192. doi: 10.1016/j.febslet.2014.01.001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [8].Qu C, Gardner P, Schrijver I. The role of the cytoskeleton in the formation of gap junctions by Connexin 30. Exp Cell Res. 2009;315:1683–1692. doi: 10.1016/j.yexcr.2009.03.001. [DOI] [PubMed] [Google Scholar]
  • [9].Oliet SH, Piet R, Poulain DA. Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science. 2001;292:923–926. doi: 10.1126/science.1059162. [DOI] [PubMed] [Google Scholar]
  • [10].Gordon GR, Baimoukhametova DV, Hewitt SA, Rajapaksha WR, Fisher TE, Bains JS. Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy. Nat Neurosci. 2005;8:1078–1086. doi: 10.1038/nn1498. [DOI] [PubMed] [Google Scholar]
  • [11].Clasadonte J, Sharif A, Baroncini M, Prevot V. Gliotransmission by prostaglandin e(2): a prerequisite for GnRH neuronal function? Front Endocrinol (Lausanne) 2011;2:91. doi: 10.3389/fendo.2011.00091. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [12].Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, et al. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat Neurosci. 2014;17:908–910. doi: 10.1038/nn.3725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [13].Allard C, Carneiro L, Grall S, Cline BH, Fioramonti X, Chrétien C, et al. Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion. J Cereb Blood Flow Metab. 2014;34:339–346. doi: 10.1038/jcbfm.2013.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [14].Condorelli DF, Mudò G, Trovato-Salinaro A, Mirone MB, Amato G, Belluardo N C. onnexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures. Mol Cell Neurosci. 2002;21:94–113. doi: 10.1006/mcne.2002.1155. [DOI] [PubMed] [Google Scholar]
  • [15].Bernard R, Kerman IA, Thompson RC, Jones EG, Bunney WE, Barchas JD, et al. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psychiatry. 2011;16:634–646. doi: 10.1038/mp.2010.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [16].Ernst C, Nagy C, Kim S, Yang JP, Deng X, Hellstrom IC, et al. Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. Biol Psychiatry. 2011;70:312–319. doi: 10.1016/j.biopsych.2011.03.038. [DOI] [PubMed] [Google Scholar]

Articles from Neuroscience Bulletin are provided here courtesy of Springer

RESOURCES