Table 4.
DENV mortality in AG129 mice for frequently used viruses.
| Virus | Dose (log10 PFU) |
n | % Mortality# | Median survival time (days) |
LD50* (log10 PFU) |
Reference |
|---|---|---|---|---|---|---|
| D2S10 | 7.0 | 15 | 93 | 4.0 | 6.6 | [55] |
| 6.0 | 8 | 0 | --- | |||
| 5.0 | 11 | 0 | --- | |||
| C0360/94 | 7.5 | 15 | 93 | 4.0 | 7.1 | [67] |
| 7.0 | 2 | 50 | 28.5 | |||
| 6.5 | 8 | 0 | --- | |||
| 703–4 | 7.3 | 8 | 100 | 4.0 | 6.8 | [74] |
| 6.3 | 8 | 0 | --- | |||
| TVP-376 | 7.5 | 2 | 100 | 3.5 | 6.5 | [75] |
| 7 | 10 | 100 | 5 | |||
| 6 | 8 | 0 | --- | |||
| S221 | 5.6 | 4 to 7 | 100 | n/a | 4.7 | [47] |
| 4.3 | 4 to 7 | 100 | n/a |
#
Percentages were calculated from published data in the referenced study.
*
LD50 calculated using Spearman-Karber calculation from data provided in the referenced study, except S221 (published LD50: 2.7×109 GE, converted to PFU)
n/a Data not available