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. 1992 Jan;11(1):25–31. doi: 10.1002/j.1460-2075.1992.tb05023.x

Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice.

P Pereira 1, M Zijlstra 1, J McMaster 1, J M Loring 1, R Jaenisch 1, S Tonegawa 1
PMCID: PMC556421  PMID: 1531458

Abstract

The gamma delta T cell receptor (TCR) of the hybridoma KN6 recognizes the self molecule encoded by a class I gene which maps within the TL region of the major histocompatibility complex (MHC) of H-2b mice. Mice transgenic (Tg) for this TCR were crossed with mice genetically deficient in beta 2-microglobulin (beta 2m). No mature Tg gamma delta T cells were detected in the thymus or the spleen of the beta 2m- gamma delta Tg mice. We conclude that interaction between the Tg gamma delta TCR and a beta 2m-associated molecule (probably an MHC class I molecule) is required for the generation of mature Tg gamma delta T cells.

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Selected References

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