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. 2017 Apr 3;8(29):47052–47063. doi: 10.18632/oncotarget.16789

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Copyright: © 2017 Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) TROP2 protein was highly expressed in GBC, lower in paracarcinoma, and undetectable in chronic cholecystitis tissues (T: GBC, N: paracarcinoma, and C: chronic cholecystitis tissues). (B) TROP2 mRNA expression in GBC was significantly higher compared to paracarcinoma (167.06±50.71 VS 1.20±0.79, P<0.05). Columns, n=28; bars, S.D. P< 0.05, GBC compared with paracarcinoma. (C) TROP2 protein expression was higher in advanced GBCs revealed by IHC staining. No TROP2 expression was detected in paracarcinoma. (D) Kaplan-Meier survival curve showed that GBC patients with high TROP2 expression had a worse prognosis.