Table 2. Demographics of 114 CHB carriers stratified according to cirrhosis status.
| Cirrhosis-positive (n = 68) | Cirrhosis-negative (n = 46) | |||||
|---|---|---|---|---|---|---|
| HCC (n = 34) | Non-HCC (n = 34) | p value | HCC (n = 23) | Non-HCC (n = 23) | p value | |
| Age#, years | 61.1 (57.7–62.9) | 62.4 (57.9–62.2) | 0.797 | 62.0 (54.2–66.7) | 60.7 (53.2–68.3) | 0.974 |
| Male#, n (%) | 20 (87.0%) | 20 (87.0%) | 1.00 | 28 (82.4%) | 28 (82.4%) | n.a. |
| HBeAg-ve#, n (%) | 22 (95.7%) | 22 (95.7%) | 1.00 | 34 (100%) | 34 (100%) | n.a. |
| Albumin, g/L | 43 (40–47) | 44 (42–46) | 0.309 | 45 (42–46) | 43 (41–46) | 0.458 |
| Bilirubin, umol/L | 11 (7–17) | 11 (9–17) | 0.927 | 12 (9–17) | 10 (8–15) | 0.183 |
| ALT, U/L | 34 (24–43) | 23 (20–29) | 0.002 | 25 (17–32) | 21 (20–28) | 0.692 |
| Platelet, x 10 ^9/L | 132 (91–170) | 153 (125–192) | 0.102 | 188 (166–215) | 208 (174–259) | 0.199 |
| INR | 1.1 (1.0–1.1) | 1.1 (1.0–1.1) | 0.385 | 1.1 (1.0–1.1) | 1.0 (1.0–1.0) | 0.166 |
| AFP, ng/mL | 11 (5–27) | 3 (2–4) | < 0.001 | 14 (7–53) | 3 (2–3) | < 0.001 |
| Undetectable DNA#, n (%) | 34 (100%) | 34 (100%) | 1.00 | 23 (100%) | 23 (100%) | n.a. |
| Duration of therapy#, years | 3.4 (2.0–5.1) | 3.7 (2.1–5.1) | 0.652 | 3.2 (2.1–4.7) | 3.4 (2.5–5.0) | 0.582 |
Continuous variables expressed as median (interquartile range).
CHB, chronic hepatitis B virus; HCC, hepatocellular carcinoma; ALT, alanine aminotransferase; INR, international normalised ratio; AFP, alpha-fetal protein.
# Matched variables.
n.a., p-value not applicable as these were matched categorical variable.