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. 2017 Mar 23;8(30):48889–48904. doi: 10.18632/oncotarget.16522

Figure 5. TIPE3 upregulated the expression of MMP2 and uPA, and promoted the activation of AKT and NF-κB.

Figure 5

The phosphorylation levels of p-AKT, p-IkBα and p-P65 were upregulated by overexpressed TIPE3 in MCF-7 cells (A) and MDA-MB-231 cells (E), and were downregulated in MDA-MB-231 cells transfected with shTIPE3 (B). The levels of MMP2 and uPA were increased in MCF-7-TIPE3 (C) and MDA-MB-231-TIPE3 (G) cells, and were decreased in MDA-MB-231-shTIPE3 cells (D). The levels of nuclear P65 were upregulated in TIPE3-overexpressed MCF-7 and MDA-MB-231 cells (F). All of the experiments were repeated at least three times with similar results and representative data are shown. (*P < 0.05, **P < 0.01 and ***P < 0.001).