Table 2. Meta-analysis results of association between rs13181 A > C polymorphism and pancreatic cancer risk.
AC vs AA | CC vs AA | AC/CC vs AA | CC vs AC/AA | C vs A | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Variables | Na | OR(95%CI) | Pb/I2(%) | OR(95%CI) | Pb/I2(%) | OR(95%CI) | Pb/I2(%) | OR(95%CI) | Pb/I2(%) | OR(95%CI) | Pb/I2(%) |
Total | 8 | 1.10(0.96-1.25) | 0.636/0.0 | 1.56(1.28-1.90) | 0.470/0.0 | 1.20(1.06-1.36) | 0.396/4.4 | 1.50(1.24-1.81) | 0.530/0.0 | 1.22(1.11-1.34) | 0.159/33.7 |
Ethnicity | |||||||||||
Asian | 5 | 1.20(1.00-1.43) | 0.584/0.0 | 1.87(1.43-2.43) | 0.770/0.0 | 1.34(1.14-1.57) | 0.534/0.0 | 1.74(1.35-2.25) | 0.718/0.0 | 1.37(1.21-1.56) | 0.507/0.0 |
Caucasian | 3 | 0.99(0.82-1.21) | 0.809/0.0 | 1.23(0.91-1.67) | 0.681/0.0 | 1.04(0.86-1.25) | 0.904/0.0 | 1.25(0.94-1.65) | 0.583/0.0 | 1.07(0.94-1.23) | 0.808/0.0 |
Source of controlc | |||||||||||
PB | 3 | 1.02(0.85-1.22) | 0.707/0.0 | 1.25(0.95-1.65) | 0.803/0.0 | 1.07(0.90-1.27) | 0.713/0.0 | 1.25(0.97-1.62) | 0.758/0.0 | 1.09(0.96-1.24) | 0.661/0.0 |
HB | 5 | 1.20(0.99-1.46) | 0.567/0.0 | 1.99(1.49-2.66) | 0.895/0.0 | 1.36(1.14-1.62) | 0.568/0.0 | 1.85(1.39-2.45) | 0.809/0.0 | 1.40(1.22-1.61) | 0.593/0.0 |
HWEd | |||||||||||
Yes | 4 | 0.99(0.82-1.19) | 0.939/0.0 | 1.52(1.14-2.01) | 0.365/5.7 | 1.09(0.92-1.29) | 0.853/0.0 | 1.53(1.17-1.99) | 0.379/2.8 | 1.16(1.02-1.32) | 0.618/0.0 |
No | 4 | 1.23(1.02-1.49) | 0.535/0.0 | 1.60(1.21-2.11) | 0.339/10.7 | 1.33(1.11-1.58) | 0.259/25.5 | 1.47(1.12-1.92) | 0.397/0.0 | 1.29(1.13-1.47) | 0.061/59.4 |
a Number of studies;
b P value of Q test for heterogeneity;
c PB, population-based; HB, hospital-based;
d HWE, Hardy-Weinberg equilibrium.