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Fabrication of the siRNA-aptamer chimera. (A) Schematic of the DNA aptamer-20 with a 14-mer sticky bridge. (B) Schematic of the siRNA-aptamer chimera. The sense strand of the PCBP2 siRNA containing a 3' sticky bridge which is complementary with the sticky bridge of aptamer-20. (C) Annealing of the siRNA-aptamer chimera was confirmed by native PAGE analysis. (D) Stability of the siRNA duplex and siRNA-aptamer chimera in Opti-MEM medium and rat serum.
