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. 1992 Jul;11(7):2367–2372. doi: 10.1002/j.1460-2075.1992.tb05300.x

Higher rate of evolution of X chromosome alpha-repeat DNA in human than in the great apes.

H B Laursen 1, A L Jørgensen 1, C Jones 1, A L Bak 1
PMCID: PMC556710  PMID: 1628610

Abstract

The rate of introduction of neutral mutations is lower in man than in other primates, including the chimpanzee. This species is generally regarded as our closest relative among the great apes. We present here an analysis of sequences of X chromosomal alphoid repetitive DNA from man and the great apes, which supports the closer relationship between man and chimpanzee and indicates a considerably increased rate of recombination in the human repeat DNA. These results indicate that the 'molecular clock' is running more quickly in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexandrov I. A., Mitkevich S. P., Yurov Y. B. The phylogeny of human chromosome specific alpha satellites. Chromosoma. 1988;96(6):443–453. doi: 10.1007/BF00303039. [DOI] [PubMed] [Google Scholar]
  2. Britten R. J. Rates of DNA sequence evolution differ between taxonomic groups. Science. 1986 Mar 21;231(4744):1393–1398. doi: 10.1126/science.3082006. [DOI] [PubMed] [Google Scholar]
  3. Devereux J., Haeberli P., Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387–395. doi: 10.1093/nar/12.1part1.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Djian P., Green H. Vectorial expansion of the involucrin gene and the relatedness of the hominoids. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8447–8451. doi: 10.1073/pnas.86.21.8447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dover G. A. DNA turnover and the molecular clock. J Mol Evol. 1987;26(1-2):47–58. doi: 10.1007/BF02111281. [DOI] [PubMed] [Google Scholar]
  6. Dover G. A. Linkage disequilibrium and molecular drive in the rDNA gene family. Genetics. 1989 May;122(1):249–252. doi: 10.1093/genetics/122.1.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dover G. Molecular drive: a cohesive mode of species evolution. Nature. 1982 Sep 9;299(5879):111–117. doi: 10.1038/299111a0. [DOI] [PubMed] [Google Scholar]
  8. Durfy S. J., Willard H. F. Concerted evolution of primate alpha satellite DNA. Evidence for an ancestral sequence shared by gorilla and human X chromosome alpha satellite. J Mol Biol. 1990 Dec 5;216(3):555–566. doi: 10.1016/0022-2836(90)90383-W. [DOI] [PubMed] [Google Scholar]
  9. Durfy S. J., Willard H. F. Patterns of intra- and interarray sequence variation in alpha satellite from the human X chromosome: evidence for short-range homogenization of tandemly repeated DNA sequences. Genomics. 1989 Nov;5(4):810–821. doi: 10.1016/0888-7543(89)90123-7. [DOI] [PubMed] [Google Scholar]
  10. Felsenstein J. Evolutionary trees from DNA sequences: a maximum likelihood approach. J Mol Evol. 1981;17(6):368–376. doi: 10.1007/BF01734359. [DOI] [PubMed] [Google Scholar]
  11. Gonzalez I. L., Sylvester J. E., Smith T. F., Stambolian D., Schmickel R. D. Ribosomal RNA gene sequences and hominoid phylogeny. Mol Biol Evol. 1990 May;7(3):203–219. doi: 10.1093/oxfordjournals.molbev.a040600. [DOI] [PubMed] [Google Scholar]
  12. Goodman M., Koop B. F., Czelusniak J., Fitch D. H., Tagle D. A., Slightom J. L. Molecular phylogeny of the family of apes and humans. Genome. 1989;31(1):316–335. doi: 10.1139/g89-050. [DOI] [PubMed] [Google Scholar]
  13. Hasegawa M., Kishino H., Hayasaka K., Horai S. Mitochondrial DNA evolution in primates: transition rate has been extremely low in the lemur. J Mol Evol. 1990 Aug;31(2):113–121. doi: 10.1007/BF02109480. [DOI] [PubMed] [Google Scholar]
  14. Jørgensen A. L., Bostock C. J., Bak A. L. Chromosome-specific subfamilies within human alphoid repetitive DNA. J Mol Biol. 1986 Jan 20;187(2):185–196. doi: 10.1016/0022-2836(86)90227-5. [DOI] [PubMed] [Google Scholar]
  15. Jørgensen A. L., Jones C., Bostock C. J., Bak A. L. Different subfamilies of alphoid repetitive DNA are present on the human and chimpanzee homologous chromosomes 21 and 22. EMBO J. 1987 Jun;6(6):1691–1696. doi: 10.1002/j.1460-2075.1987.tb02419.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Jørgensen A. L., Laursen H. B., Jones C., Bak A. L. Evolutionarily different alphoid repeat DNA on homologous chromosomes in human and chimpanzee. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3310–3314. doi: 10.1073/pnas.89.8.3310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kishino H., Hasegawa M. Evaluation of the maximum likelihood estimate of the evolutionary tree topologies from DNA sequence data, and the branching order in hominoidea. J Mol Evol. 1989 Aug;29(2):170–179. doi: 10.1007/BF02100115. [DOI] [PubMed] [Google Scholar]
  18. Koop B. F., Goodman M., Xu P., Chan K., Slightom J. L. Primate eta-globin DNA sequences and man's place among the great apes. Nature. 1986 Jan 16;319(6050):234–238. doi: 10.1038/319234a0. [DOI] [PubMed] [Google Scholar]
  19. Li W. H., Tanimura M. The molecular clock runs more slowly in man than in apes and monkeys. Nature. 1987 Mar 5;326(6108):93–96. doi: 10.1038/326093a0. [DOI] [PubMed] [Google Scholar]
  20. Mahtani M. M., Willard H. F. Pulsed-field gel analysis of alpha-satellite DNA at the human X chromosome centromere: high-frequency polymorphisms and array size estimate. Genomics. 1990 Aug;7(4):607–613. doi: 10.1016/0888-7543(90)90206-a. [DOI] [PubMed] [Google Scholar]
  21. Masumoto H., Masukata H., Muro Y., Nozaki N., Okazaki T. A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite. J Cell Biol. 1989 Nov;109(5):1963–1973. doi: 10.1083/jcb.109.5.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Miyamoto M. M., Slightom J. L., Goodman M. Phylogenetic relations of humans and African apes from DNA sequences in the psi eta-globin region. Science. 1987 Oct 16;238(4825):369–373. doi: 10.1126/science.3116671. [DOI] [PubMed] [Google Scholar]
  23. Okumura K., Kiyama R., Oishi M. Sequence analyses of extrachromosomal Sau3A and related family DNA: analysis of recombination in the excision event. Nucleic Acids Res. 1987 Sep 25;15(18):7477–7489. doi: 10.1093/nar/15.18.7477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ruvolo M., Disotell T. R., Allard M. W., Brown W. M., Honeycutt R. L. Resolution of the African hominoid trichotomy by use of a mitochondrial gene sequence. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1570–1574. doi: 10.1073/pnas.88.4.1570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Sibley C. G., Ahlquist J. E. DNA hybridization evidence of hominoid phylogeny: results from an expanded data set. J Mol Evol. 1987;26(1-2):99–121. doi: 10.1007/BF02111285. [DOI] [PubMed] [Google Scholar]
  26. Sibley C. G., Comstock J. A., Ahlquist J. E. DNA hybridization evidence of hominoid phylogeny: a reanalysis of the data. J Mol Evol. 1990 Mar;30(3):202–236. doi: 10.1007/BF02099992. [DOI] [PubMed] [Google Scholar]
  27. Smith G. P. Evolution of repeated DNA sequences by unequal crossover. Science. 1976 Feb 13;191(4227):528–535. doi: 10.1126/science.1251186. [DOI] [PubMed] [Google Scholar]
  28. Ueda S., Watanabe Y., Saitou N., Omoto K., Hayashida H., Miyata T., Hisajima H., Honjo T. Nucleotide sequences of immunoglobulin-epsilon pseudogenes in man and apes and their phylogenetic relationships. J Mol Biol. 1989 Jan 5;205(1):85–90. doi: 10.1016/0022-2836(89)90366-5. [DOI] [PubMed] [Google Scholar]
  29. Waye J. S., Creeper L. A., Willard H. F. Organization and evolution of alpha satellite DNA from human chromosome 11. Chromosoma. 1987;95(3):182–188. doi: 10.1007/BF00330349. [DOI] [PubMed] [Google Scholar]
  30. Waye J. S., Durfy S. J., Pinkel D., Kenwrick S., Patterson M., Davies K. E., Willard H. F. Chromosome-specific alpha satellite DNA from human chromosome 1: hierarchical structure and genomic organization of a polymorphic domain spanning several hundred kilobase pairs of centromeric DNA. Genomics. 1987 Sep;1(1):43–51. doi: 10.1016/0888-7543(87)90103-0. [DOI] [PubMed] [Google Scholar]
  31. Waye J. S., Willard H. F. Chromosome-specific alpha satellite DNA: nucleotide sequence analysis of the 2.0 kilobasepair repeat from the human X chromosome. Nucleic Acids Res. 1985 Apr 25;13(8):2731–2743. doi: 10.1093/nar/13.8.2731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Waye J. S., Willard H. F. Concerted evolution of alpha satellite DNA: evidence for species specificity and a general lack of sequence conservation among alphoid sequences of higher primates. Chromosoma. 1989 Oct;98(4):273–279. doi: 10.1007/BF00327313. [DOI] [PubMed] [Google Scholar]
  33. Waye J. S., Willard H. F. Nucleotide sequence heterogeneity of alpha satellite repetitive DNA: a survey of alphoid sequences from different human chromosomes. Nucleic Acids Res. 1987 Sep 25;15(18):7549–7569. doi: 10.1093/nar/15.18.7549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Waye J. S., Willard H. F. Structure, organization, and sequence of alpha satellite DNA from human chromosome 17: evidence for evolution by unequal crossing-over and an ancestral pentamer repeat shared with the human X chromosome. Mol Cell Biol. 1986 Sep;6(9):3156–3165. doi: 10.1128/mcb.6.9.3156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Willard H. F. Chromosome-specific organization of human alpha satellite DNA. Am J Hum Genet. 1985 May;37(3):524–532. [PMC free article] [PubMed] [Google Scholar]
  36. Willard H. F., Waye J. S. Chromosome-specific subsets of human alpha satellite DNA: analysis of sequence divergence within and between chromosomal subsets and evidence for an ancestral pentameric repeat. J Mol Evol. 1987;25(3):207–214. doi: 10.1007/BF02100014. [DOI] [PubMed] [Google Scholar]

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