Body weights (A) and heart weights (B) of mice treated with vehicle (saline, n = 7), PACAP (10 μg, i.p., n = 7), MXT (3 mg/kg, i.p., n = 5–7) or PACAP+MXT (n = 7) on days 1, 7, 14, and 21. PACAP was also given to the PACAP and PACAP+MXT groups 24 and 48 h after the first dose of PACAP. MXT, mitoxantrone; PACAP, pituitary adenylate cyclase activating polypeptide. * p < 0.05 versus the saline group. # p < 0.05 MXT group versus the PACAP+MXT group.