Abstract
Background
We aimed to define characteristics of TB patients in Puducherry and two districts of Tamil Nadu, India and calculate the population attributable fractions (PAF) of TB from malnutrition and alcohol.
Methods
New smear-positive TB cases were enrolled into the Regional Prospective Observational Research for Tuberculosis (RePORT India) cohort. Census and National Family Health Survey data were used for comparisons.
Results
Data were analyzed for 409 participants enrolled between May 2014-June 2016; 307 (75.1%) were male, 60.2% were malnourished (body mass index [BMI] <18.5 kg/m2), and 29.1% severely malnourished (BMI <16). “Hazardous” alcohol use (based on AUDIT-C score) was reported by 155/305 (50.8%) of males. Tuberculosis cases were more likely than the Puducherry population to be malnourished (62.6% v 10.2% males and 71.7% v 11.3% of females; both p<0.001), and male cases were more likely to use alcohol than male non-cases (84.4% v 41%; p < .001). The PAF of malnutrition was 57.4% in males and 61.5% in females; the PAF for alcohol use was 73.8% in males and 1.7% in females.
Conclusions
Alcohol use in men and malnutrition are helping drive the TB epidemic in Southern India. Reducing the TB burden in this population will require efforts to mitigate these risk factors.
Introduction
An estimated 10.6 million cases of tuberculosis (TB) occur annually in the world, and India accounts for 27% of these.[1] The emergence of drug-resistant TB creates a renewed sense of urgency to control the disease. A global expert consultation identified cross-cutting, academic-governmental research partnerships as important, cost-effective platforms for research.[2] Our cohort is part of the Regional Prospective Observational Research for Tuberculosis (RePORT India) Consortium, jointly funded by the Government of India’s Department of Biotechnology, the Indian Council of Medical Research, and the United States National Institutes of Health, and distributed in part by the U.S. Civilian Research & Development Foundation.[3] This Indo-US partnership establishes prospective observational cohorts using clinical, laboratory, and data standards and a linked bio-repository of well-characterized specimens to identify biomarkers of treatment failure and relapse.[3] The use of common data points across RePORT sites in India, South Africa, Brazil and elsewhere will enable comparison and aggregation of data at a supranational level.[3,4]
The WHO End TB strategy has identified the need for “country-specific TB research plans.”[2] In a country as diverse as India, this requires understanding regional differences in the key risk factors for TB. Furthermore, defining characteristics of those who engage in TB care through the public Revised National TB Control Programme (RNTCP) versus private clinics will help programs direct resources. The objectives of this paper are to describe the characteristics of new TB patients seeking care at RNTCP clinics in Puducherry and Tamil Nadu, India; to compare these cases with the overall population and delineate regional characteristics and risk factors; and to define the population attributable fractions (PAF) for key comorbidities. Identification of factors with high population attributable fractions will provide guidance to the local RNTCP on factors that could be addressed to reduce the local burden of TB.
Materials and methods
Study setting
The study is an observational household contact (cohort) study conducted by Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) in collaboration with Boston University Medical Campus and Rutgers University. In Puducherry (population ~9.5million), there is one TB Unit (TU), and enrollment began in May 2014. Of the 32 districts of Tamil Nadu, Cuddalore (population 2.6 million) and Villapuram (population 3.5 million) are adjacent to Puducherry; two TUs were selected in each district (population served is approximately 500,000 per TU). Enrollment began in Cuddalore in August 2014 and Villapuram in November 2015.
Study design
Patients were recruited from RNTCP district microscopy centers and primary healthcare centers. Written informed consent was obtained from all individuals meeting study inclusion criteria who consented to participate. Inclusion criteria include: 1. Newly diagnosed smear-positive (at least 1+ acid fast bacilli [AFB]), culture-confirmed pulmonary TB. 2. Having taken < three doses of anti-TB medication. 3. No history of TB or TB treatment. 4. Plan to stay in study area for the study duration. 5. >5 years of age. Exclusion criteria include: 1. Unwilling to be tested for HIV. 2. Diagnosis of or contact with someone with known multi-drug resistant-TB. 3. Choose not to initiate TB treatment; or 4. Too sick to enroll, defined as a Karnofsky score ≤ 10 (moribund).[5]
Study procedures
Upon enrollment, study personnel administered a questionnaire to assess demographic and clinical characteristics including age, gender, marital status, religion, caste, education level, other socioeconomic characteristics, TB symptoms and duration, comorbidities, and Karnofsy score. [5] Participants were asked about alcohol use using the Alcohol Use Disorders Identification Test (AUDIT)-C questionnaire (a modified version of AUDIT),[6] and smoking, including the product (e.g., bidis, store bought cigarettes), frequency and duration of use. Baseline anthropometric measurements included body mass index (BMI) and mid upper arm circumference. One follow-up visit was performed between weeks 8–12 and another at treatment completion. Questions were translated into Tamil and administered by Tamil-speaking interviewers. A random sputum sample was collected at enrollment for concentrated AFB smear and Löwenstein–Jensen and mycobacterial growth indicator tube (MGIT) cultures.
Measurements and definitions
Diabetes was defined as random blood sugar >200mg/dL or self-report; severe malnutrition was defined as BMI <16 kg/m2 and malnutrition as BMI 16–18.5 kg/m2. Anemia was defined as hemoglobin < 13 g/dl for men and < 12 g/dl for women.[7] “Hazardous” alcohol use was defined as per AUDIT-C.[8] Scheduled caste is the lowest caste, and members are awarded special government benefits; “other backwards caste” is above scheduled caste but below all others.[9]
Data sources
Population data came from the Indian 2011 census (for demographics and assets)[10] and the 2015 National Family Health Survey (NFHS) (for health, BMI and alcohol data).[7] The NFHS reported any current alcohol use (not hazardous use). This study protocol was reviewed and approved by the Boston University Medical Campus and Rutgers Institutional Review Boards. The study was also approved by the JIPMER Ethics Committee and Scientific Advisory Committee. Consent was obtained from participants; for minors, assent was obtained as well as parental consent.
Data management and statistical analysis
Paper questionnaires were scanned, sent to Boston using Verity TeleForm Information Capture System software V10.8 (Sunnyvale, CA, USA), and read into a Microsoft Access (Seattle, WA, USA) database. Errors were reviewed and corrected by the on-site team. Data analyses were performed using SAS V9.4 (Cary, NC, USA). Dichotomous variables were compared using the chi square test and continuous variables using the two-sample two-sided t-test. Comparisons to the census and NFHS data were made and p-values calculated using chi-square tests for differences in proportions between the two samples. The PAFs for malnutrition and alcohol use in Puducherry alone were calculated for those aged 15–49 years using the equation PAF = Ppop*(RR-1)/[(Ppop*(RR-1)+1] where Ppop is the prevalence of the exposure in the population (based on NFHS data) and RR is the relative risk of TB (using study data for Puducherry and the 2011 census data for Puducherry)[11]. Because the NFHS included only persons 15–49 years old, the comparison analysis was performed using study data for those aged 15–49 years. The PAFs do not control for potential confounders or effect modifiers.
Results
Demographics
Of the 549 smear-positive TB patients evaluated in RNTCP clinics between May 2014-June 2016 and screened for study enrollment, 409 (74.5%) consented to participate. Of the 140 not enrolled, 135 (96.4%) were ≥18 years of age and 105 (75%) male. Of those enrolled, 307/409 (75.1%) were male, the mean age was 45 years (range 14–81), and 283 (69.9%) were married (Table 1). Almost all (98.0%) participants were from a scheduled or other backwards caste. Index cases had a median of 7 years of education (range 0–18) and their mothers a median of 0 years (range 0–15). Over half (54.3%) of cases first sought care at a private clinic. Households had a median of 4 people (range 1–13). Household characteristics were available for 185 index cases for whom household contacts were also enrolled. Monthly household income was <5000 rupees (approximately $79) for 52.6%.
Table 1. Characteristics of TB patients in RePORT cohort, Puducherry and Tamil Nadu, (2014–16).
| Male, n (%) (n = 307) |
Female, n (%) (n = 102) |
Total, n (%) (n = 409) |
|
|---|---|---|---|
| Demographic Characteristics | |||
| Male gender | 307 (100) | 0 (0) | 307 (75.1) |
| Age (mean, range) | 47 (17–81) | 34 (14–75) | 45 (14–81) |
| Marital status | |||
| Married/living together | 243/305 (79.7) | 40/100 (40.0) | 283/405 (69.9) |
| Never married | 33/305 (10.8) | 31/100 (31.0) | 64/405 (15.8) |
| Widowed | 18/305 (5.9) | 26/100 (26.0) | 44/405 (10.9) |
| Separated/divorced | 11/305 (3.6) | 3/100 (3.0) | 14/405 (3.5) |
| Caste/Tribea | |||
| Other backwards caste | 222/305 (72.8) | 74/100 (74.0) | 296/405 (73.1) |
| Scheduled Caste | 77/305 (25.2) | 24/100 (24.0) | 101/405 (24.9) |
| None of them | 3/305 (1.0) | 2/100 (2.0) | 5/405 (1.23) |
| Don’t Know | 3/305 (1.0) | 0 (0) | 3/405 (0.74) |
| Employment/occupation | |||
| Employed | 282/304 (92.8) | 41/100 (41.0) | 323/404 (80.0) |
| Unemployed | 12/304 (3.95) | 37/100 (37.0) | 49/404 (12.1) |
| Student | 7/304 (2.3) | 22/100 (22.0) | 29/404 (7.2) |
| Other | 3/304 (0.99) | 0 (0) | 3/404 (0.74) |
| Education, years; median (range) | 7 (0–18) | 9 (0–17) | 7 (0–18) |
| Maternal education, years; median (range) | 0 (0–12) | 0 (0–15) | 0 (0–15) |
| No. people in household; median (range) | 4 (1–9) | 4 (1–13) | 4 (1–13) |
| Monthly household income | |||
| <Rs 3000 ($48) | 50/305 (16.4) | 11/100 (11.0) | 61/405 (15.1) |
| Rs 3000–5000 ($48–79) | 108/305 (35.4) | 44/100 (44.0) | 152/405 (37.5) |
| Rs 5001–10000 ($79–158) | 108/305 (35.4) | 29/100 (29.0) | 137/405 (33.8) |
| > Rs 10000 (>$158) | 34/305 (11.1) | 11/100 (11.0) | 45/405 (11.1) |
| Refused to Answer | 1/305 (0.3) | 3/100 (3.0) | 4/405 (1.0) |
| Don’t Know | 4/305 (1.3) | 2/100 (2.0) | 6/405 (1.5) |
| Comorbidities | |||
| Smoking status | |||
| Current smoker | 60/305 (19.7) | 0 (0) | 60/405 (14.8) |
| Former smoker | 136/305 (44.6) | 1/100 (1.0) | 137/405 (33.8) |
| Alcohol | |||
| Any use | 246/305 (80.7) | 2/100 (2.0) | 248/405 (61.2) |
| Hazardous useb | 155/305 (50.8) | 2/100 (2.0) | 157/405 (38.8) |
| BMI, kg/m2 | |||
| <16 | 91/305 (29.8) | 27/100 (27.0) | 118/405 (29.1) |
| 16–18.5 | 94/305 (30.8) | 32/100 (32.0) | 126/405 (31.1) |
| 18.6–24.9 | 109/305 (35.7) | 32/100 (32.0) | 141/405 (34.8) |
| 25–29.9 | 10/305 (3.3) | 8/100 (8.0) | 18/405 (4.4) |
| >30 | 1/305 (0.3) | 1/100 (1.0) | 2/405 (0.5) |
| Diabetes mellitus | |||
| Self-report | 90/291 (30.9) | 28/96 (29.2) | 118/387 (30.5) |
| Random blood sugar >200 mg/dL | 86/305 (28.2) | 27/100 (27.0) | 113/405 (27.9) |
| Self-report or random blood sugar | 111/305 (36.4) | 33/100 (33.0) | 144/409 (35.2) |
| HIV-infected (n = 383) | 0 (0) | 1 (1.1) | 1 (0.3) |
a Scheduled castes are the lowest caste and receive government benefits. Other backwards caste is a collective term to classify castes that are socially and educationally disadvantaged.
b Hazardous alcohol use is defined based on AUDIT-C score.
Comorbidities
Among males, 60 (19.7%) were current smokers and 136 (44.6%) former smokers; only one female was a former smoker and none were current smokers. Any alcohol use was reported by 246 (80.7%) males and two (2.0%) females and hazardous alcohol use by 155 (50.8%) and two (2.0%), respectively. Among TB cases, 60.2% were malnourished including 29.1% who were severely malnourished. In total, 144 (35.2%) had diabetes as determined by self-report (n = 118 [30.5%]) and/or random blood sugar >200 mg/dL (n = 113 [27.9%]).
Comparison with population and population attributable fractions
Comparing the TB cases in the RePORT cohort and the Puducherry population, the former had a greater proportion of males (75.1% vs 49.1%, p<0.001) and tended to be older (Table 2). Data on household income were not available from the Census or NFHS, so we compared other measures of socioeconomic status. A larger proportion in RePORT were scheduled caste than in the population (26.4% vs. 15.7%; p = 0.06), more had cement floors (72.4% vs 56.5%, p = 0.02), and fewer had tile floors (16.2 vs. 29; p = 0.03) or a private water source (45.7% vs. 80.5%; p<0.001). The TB cases were more likely to be malnourished than the Puducherry general population (71.7% vs. 11.3% of females; p<0.001, and 62.6% vs. 10.2% of males; p < .001; Table 3). Male TB cases were also more likely to use alcohol (84.4% of study population vs. 41% in Puducherry; p<0.001). The PAF of malnutrition was 57.4% in males and 61.5% in females; the PAF for alcohol use was 73.8% in males and 1.7% in females.
Table 2. Comparison of TB case characteristics, household characteristics and Puducherry population based on 2011 census data.
| Study cohort (n = 409) |
Puducherry population (%) | p-value | OR (95% CI) |
|
|---|---|---|---|---|
| Male, % | 75.1 | 49.1 | <0.001 | 3.26 (1.8–5.9) |
| Age categories, years % | ||||
| < 20 | 16.1 | 33.9 | <0.001 | 0.37 (0.2–0.7) |
| 20–29 | 11.5 | 18.5 | 0.17 | 0.57 (.3–1.3) |
| 30–39 | 13.7 | 17.3 | 0.48 | 0.75 (.4–1.6) |
| 40–49 | 22.9 | 13.1 | 0.07 | 1.9 (0.9–4.2) |
| 50–59 | 19.9 | 8.6 | 0.02 | 2.6 (1.1–6.2) |
| 60–69 | 13.0 | 5.3 | 0.06 | 2.7 (0.9–7.6) |
| 70–79 | 2.7 | 2.3 | 0.86 | 1.2 (0.2–7.0) |
| 80+ | 0.22 | 1.0 | 0.48 | 0.2 (<0.1–24.3) |
| Scheduled caste, % | 26.4 | 15.7 | 0.06 | 1.9 (1.0–3.9) |
| Marital Status, % | ||||
| Never married | 16.4 | 27.6 | <0.001 | 0.5 (0.3–1.0) |
| Married | 69.4 | 50.7 | <0.001 | 2.2 (1.2–3.9) |
| Other | 14.3 | 7.5 | 0.12 | 2.1 (0.8–5.2) |
| Mean number of household members | 3.5 | 4.1 | <0.001 | |
| Assets | ||||
| Bicycle | 70.4 | 52.2 | 0.01 | 2.2 (1.2–3.9) |
| Phonea | 98.9 | 82.5 | <0.001 | 19.1 (2.7–133.9) |
| Radio | 19.4 | 25.0 | 0.34 | 0.7 (0.4–1.4) |
| TV | 98.4 | 84.0 | <0.001 | 11.7 (2.2–61.1) |
| Car | 0 | 5.7 | 0.02 | NA |
| Ownership of home | 61.3 | 64.3 | 0.66 | 0.9 (0.5–1.6) |
| Roof material | ||||
| Thatch/Grass | 20.5 | 17.4 | 0.58 | 1.2 (0.6–2.5) |
| Concrete | 53.5 | 64.0 | 0.13 | 0.7 (0.4–1.1) |
| Asbestos sheets | 16.7 | 7.9 | 0.06 | 2.3 (1.0–5.7) |
| Other | 9.2 | 10.7 | 0.72 | 0.8 (0.3–2.1) |
| Floor material | ||||
| Cement | 72.4 | 56.5 | 0.02 | 2.0 (1.1–3.6) |
| Tile | 16.2 | 29.0 | 0.03 | 0.5 (0.2–0.9) |
| Mud/Earth/Sand | 7.0 | 9.0 | 0.47 | 0.8 (.3–2.1) |
| Other | 4.3 | 5.5 | 0.69 | 0.8 (0.2–2.8) |
| Water source for home | ||||
| Private | 45.7 | 80.5 | <0.001 | 0.2 (0.1–0.4) |
| Near premises | 45.2 | 18.7 | <0.001 | 3.6 (1.9–6.8) |
| Other | 9.1 | 0.8 | 0.007 | 12.4 (1.2–124.2) |
a Mobile phone or land-line telephone
Table 3. Comparison of TB case characteristics and the 2015 national family health survey for Puducherry for persons ages 15–49 yearsa.
| Study cohort (%) | Puducherry population (%) | p-value | OR (95% CI) | |
|---|---|---|---|---|
| BMI <18.5, % | ||||
| Women | 71.7 | 11.3 | <0.001 | 19.9 (9.3–42.4) |
| Men | 62.6 | 10.2 | <0.001 | 14.7 (6.9–31.6) |
| BMI > 25, % | ||||
| Women | 6.7 | 36.7 | <0.001 | 0.12 (0.1–0.3) |
| Men | 3.9 | 37.1 | <0.001 | 0.07 (0.02–0.2) |
| Current Smokers, % | ||||
| Women | 0 | 1.1 | 0.62 | NA |
| Men | 18.9 | 14.4 | 0.39 | 1.4 (0.7–2.9) |
| Alcohol Use, % b | ||||
| Women | 1.7 | 0.6 | 0.23 | 2.9 (0.2–55.1) |
| Men | 84.4 | 41.0 | <0.001 | 7.8 (3.9–15.2) |
aNational Family Health Survey (NFHS) Comparison Data only includes those that are aged 15–49; study population includes only those in the same age category
bNFHS reports any alcohol use; comparable data are reported from the study cohort
Clinical and microbiologic data
Individuals were symptomatic for a median of 4 weeks (range 1–12) before starting treatment; the symptom of longest duration was weight loss. All but two had cough (406; 99.5%), and median cough duration was 4 weeks (range 1–7). Overall, 374 (92.1%) reported weight loss.
Discussion
This study uses the JIPMER RePORT cohort to define the characteristics of new smear-positive pulmonary TB patients in Puducherry and Tamil Nadu, India who access RNTCP clinics. These TB patients tend to be male, of poor socioeconomic status (based on household income, home construction and access to water) and malnourished; many of the men are hazardous alcohol users. In this region, malnutrition and alcohol use, both potentially reversible risk factors, are key drivers of TB disease. Defining the characteristics of TB patients in Puducherry and Tamil Nadu allows for targeted public health programs which may vary regionally in a country as diverse as India.
Among our male patients age 15–49 years, the PAF of alcoholism is 73.8%. In India as a whole, the PAF of TB due to alcohol “misuse” has previously been calculated to be 5–6.9%,[12,13] but our data suggest this association is far stronger in Puducherry and Tamil Nadu. In this region, it is possible that up to three-quarters of male TB cases could be eliminated if the impact of alcohol were mitigated. The striking differences in alcohol use (and hazardous alcohol use) may also explain some of the sex imbalances in TB cases in India and in our study population (where the PAF for alcohol in women was only 1.7%).[14] Alcohol treatment programs are few in this area and more may be needed;[15] by reducing alcohol use, TB cases would be fewer.[12,16] Furthermore, alcohol use results in poor TB treatment adherence and worse TB outcomes, including death;[17,18] closer integration between TB control programs and alcohol treatment programs may improve outcomes.[19–21] Currently RTNCP recommends practitioners elicit a history of alcohol use and advise patients to abstain from alcohol.[21] Use of the AUDIT-C scale in RNTCP programs could improve detection of hazardous alcohol use and identify patients that need directed services.[16] Notably, alcohol use among TB cases varies widely in India with rates of 29% in Chennai[20] and 20% in Karnataka.[22] Differences in alcohol use by location may reflect the cost, as the price and taxation rate (e.g., value added tax [VAT]) vary by state (S. Sarkar, personal communication). The integration of alcohol treatment into TB programs may therefore be less critical in some areas of India, but it certainly could have value for our site.
Among our patients, the PAF of malnutrition is 57.4% in males and 61.5% in females age 15–49 years. The high PAF of TB due to malnutrition is of particular importance, because India has a high burden of malnutrition (greater than one-third of those age 15–49 years).[23] By comparison, in 22 high TB-burden countries, the PAF of malnutrition has been reported to be only 26.9%.[12] It is plausible that some of the malnutrition is secondary to TB itself (particularly given the high rates of weight loss reported by participants), but malnutrition is also a clear risk factor for TB. Many studies have found increased TB incidence from malnutrition, including a 12.4-fold increased hazard of developing TB for those with BMI <18.5 kg/m2 and a log-linear relationship between TB incidence and BMI.[24–26] The known impact of malnutrition on TB disease severity, treatment outcomes, relapse, and mortality suggest that TB programs, particularly in countries such as India, should address nutrition.[24–26] This effort will require enhanced collaboration between government sectors, as “social protection, poverty alleviation, and actions on other determinants of TB” are critical components of the EndTB strategy.[27]
Although we did not have comparison data to calculate the regional PAF for diabetes mellitus and TB, the high prevalence in this cohort is of serious concern given the increased risk of TB and rising prevalence in India.[28] Diabetes is found in more than 65.1 million people in India (second only to China in absolute numbers),[29] and approximately one-third of TB cases in India;[30] country-wide, 9.1% of TB cases are attributable to diabetes.[12] Diabetes not only increases the risk of TB infection and progression to active TB but also contributes to treatment failure, relapse, death.[31,32] Our data also suggest that almost 1/5 diabetics are not aware of their diagnosis; increased testing may be warranted.
The fact that one-third of our cohort were former smokers and 14.8% currently smoked will have implications for TB outcomes. Smoking exacerbates the long-term damage caused by TB including fibrosis, bronchiectasis, and chronic obstructive pulmonary disease.[33,34] Furthermore, it is concerning that 14.4% of males in the greater Puducherry population smoke, because smokers have an increased odds of Mycobacterium tuberculosis infection and active TB disease.[35]
There are several strengths and limitations to this study. Study strengths include the high participation rate and the fact that the study population reflects the majority of new smear-positive pulmonary TB cases seeking care at RNTCP clinics in the catchment area. Furthermore, the use of validated questionnaires (e.g. AUDIT-C) to assess demographics and comorbidities will allow for valuable comparisons with other cohorts in India and elsewhere. The interpretation of PAFs is limited by the fact that the study cohort appears to be a poorer subset of the Puducherry and Tamil Nadu populations, and socioeconomic status may confound the association between TB and malnutrition and alcohol. Furthermore, we used comparator census and NFHS data from Puducherry alone and not Tamil Nadu to reflect the distribution of cases (78.5% are from Puducherry). The study populations and cases in these neighboring areas are very similar when comparing census data on literacy and household condition, among other factors.[7,10] Moreover, available census and NFHS data are from 2011 and 2015, respectively. It is possible that population characteristics changed somewhat between 2011 and 2015; however, we doubt such changes were substantial enough to have altered our findings.
Conclusion
This analysis provides insight into the characteristics of new smear-positive TB patients accessing care through RNTCP in Puducherry and Tamil Nadu and the drivers of TB in this region. As attention is increasingly paid to the division between public and private TB care in India, our results are most relevant to those receiving care from RNTCP. In this population, recognizing the important role of alcohol use, malnutrition, diabetes, and other factors will enable public health programs to target region-specific high-risk conditions in the fight against TB.
Supporting information
(SAS7BDAT)
Acknowledgments
We thank all of the participants who made the study possible. We also acknowledge the dedication and hard work of the field staff and study team.
Data Availability
All data is available in the Supplemental File.
Funding Statement
This work was supported by Award No. USB1-31150-XX-13 of the U.S. Civilian Research & Development Foundation (CRDF Global) and by the National Science Foundation under Cooperative Agreement No. OISE-9531011. This project has been funded in whole or in part with Federal funds from the Government of India’s (GOI) Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), the United States National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Office of AIDS Research (OAR), and distributed in part by CRDF Global. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the DBT, the ICMR, the NIH, or CRDF Global. Any mention of trade names, commercial projects, or organizations does not imply endorsement by any of the sponsoring organizations. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Data Availability Statement
All data is available in the Supplemental File.