Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

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Fig. 5E and supplemental Fig. S3A contained inadvertent image duplications. These errors have been corrected and do not affect the results or conclusions of this work.