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. 1984 Jan;3(1):185–191. doi: 10.1002/j.1460-2075.1984.tb01782.x

Evolution of a multigene family of V kappa germ line genes.

R Joho, H Gershenfeld, I L Weissman
PMCID: PMC557318  PMID: 6546718

Abstract

We have isolated a series of related V kappa germ line genes from a BALB/c sperm DNA library. DNA sequence analysis of four members of this V kappa 24 multigene family implies that three V kappa genes are functional whereas the fourth one (psi V kappa 24) is a pseudogene. The prototype gene (V kappa 24) encodes the variable region gene segment expressed in an immune response against phosphorylcholine. The other two functional genes (V kappa 24A and V kappa 24B) may be expressed against streptococcal group A carbohydrate. The time of divergence of the four genes was estimated by the rate of synonymous nucleotide changes. This implies that an ancestral gene has duplicated approximately 33-35 million years ago and a subsequent gene duplication event has occurred approximately 23 million years ago.

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Selected References

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