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. 1984 Feb;3(2):339–341. doi: 10.1002/j.1460-2075.1984.tb01808.x

Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21.

R Leberman, U Egner
PMCID: PMC557346  PMID: 6609071

Abstract

An examination of the available amino acid sequences of GTP-binding proteins has revealed that each contains a polypeptide essentially homologous for all of them. These sequences for elongation factor-Tu (EF-Tu) and the human bladder protein p21 exhibit a singular degree of homology (50%). Chemical and structural evidence indicates that this sequence in EF-Tu constitutes part of the nucleotide-binding site. The homologous sequences may therefore contribute to the GTP-binding sites of the other proteins.

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Selected References

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