Skip to main content
NCBI home page
The EMBO Journal logoLink to The EMBO Journal
. 1984 Jul;3(7):1451–1454. doi: 10.1002/j.1460-2075.1984.tb01995.x

The three-dimensional structure of retinol-binding protein.

M E Newcomer, T A Jones, J Aqvist, J Sundelin, U Eriksson, L Rask, P A Peterson
PMCID: PMC557543  PMID: 6540172

Abstract

The complex of retinol with its carrier protein, retinol-binding protein (RBP) has been crystallized and its three-dimensional structure determined using X-ray crystallography. Its most striking feature is an eight-stranded up-and-down beta barrel core that completely encapsulates the retinol molecule. The retinol molecule lies along the axis of the barrel with the beta-ionone ring innermost and the tip of the isoprene tail close to the surface.

Full text

PDF
1451

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blake C. C., Geisow M. J., Oatley S. J., Rérat B., Rérat C. Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A. J Mol Biol. 1978 May 25;121(3):339–356. doi: 10.1016/0022-2836(78)90368-6. [DOI] [PubMed] [Google Scholar]
  2. Chothia C., Janin J. Orthogonal packing of beta-pleated sheets in proteins. Biochemistry. 1982 Aug 17;21(17):3955–3965. doi: 10.1021/bi00260a009. [DOI] [PubMed] [Google Scholar]
  3. Hase J., Kobashi K., Nakai N., Onosaka S. Binding of retinol-binding protein obtained from human urine with vitamin A derivatives and terpenoids. J Biochem. 1976 Feb;79(2):373–380. doi: 10.1093/oxfordjournals.jbchem.a131080. [DOI] [PubMed] [Google Scholar]
  4. Murthy M. R., Reid T. J., 3rd, Sicignano A., Tanaka N., Rossmann M. G. Structure of beef liver catalase. J Mol Biol. 1981 Oct 25;152(2):465–499. doi: 10.1016/0022-2836(81)90254-0. [DOI] [PubMed] [Google Scholar]
  5. Newcomer M. E., Liljas A., Eriksson U., Sundelin J., Rask L., Peterson P. A. Crystallization of and preliminary X-ray data for an intracellular vitamin A-binding protein from rat liver. J Biol Chem. 1981 Aug 10;256(15):8162–8163. [PubMed] [Google Scholar]
  6. Newcomer M. E., Liljas A., Sundelin J., Rask L., Peterson P. A. Crystallization of and preliminary X-ray data for the plasma retinol-binding protein. J Biol Chem. 1984 Apr 25;259(8):5230–5231. [PubMed] [Google Scholar]
  7. Olson J. A. Recent developments in the fat-soluble vitamins. Metabolism and function of vitamin A. Fed Proc. 1969 Sep-Oct;28(5):1670–1677. [PubMed] [Google Scholar]
  8. Peterson P. A. Demonstration in serum of two physiological forms of the human retinol binding protein. Eur J Clin Invest. 1971 Sep;1(6):437–444. doi: 10.1111/j.1365-2362.1971.tb00555.x. [DOI] [PubMed] [Google Scholar]
  9. Peterson P. A., Rask L., Helting T., Ostberg L., Fernstedt Y. Formation and properties of retinylphosphate galactose. J Biol Chem. 1976 Aug 25;251(16):4986–4995. [PubMed] [Google Scholar]
  10. Rask L., Anundi H., Böhme J., Eriksson U., Fredriksson A., Nilsson S. F., Ronne H., Vahlquist A., Peterson P. A. The retinol-binding protein. Scand J Clin Lab Invest Suppl. 1980;154:45–61. [PubMed] [Google Scholar]
  11. Rask L., Anundi H., Böhme J., Eriksson U., Ronne H., Sege K., Peterson P. A. Structural and functional studies of vitamin A-binding proteins. Ann N Y Acad Sci. 1981 Feb 27;359:79–90. doi: 10.1111/j.1749-6632.1981.tb12739.x. [DOI] [PubMed] [Google Scholar]
  12. Rask L., Anundi H., Peterson P. A. The primary structure of the human retinol-binding protein. FEBS Lett. 1979 Aug 1;104(1):55–58. doi: 10.1016/0014-5793(79)81084-4. [DOI] [PubMed] [Google Scholar]
  13. Rask L., Valtersson C., Anundi H., Kvist S., Eriksson U., Dallner G., Peterson P. A. Subcellular localization in normal and vitamin A-deficient rat liver of vitamin A serum transport proteins, albumin, ceruloplasmin and class I major histocompatibility antigens. Exp Cell Res. 1983 Jan;143(1):91–102. doi: 10.1016/0014-4827(83)90112-x. [DOI] [PubMed] [Google Scholar]
  14. Richardson J. S. The anatomy and taxonomy of protein structure. Adv Protein Chem. 1981;34:167–339. doi: 10.1016/s0065-3233(08)60520-3. [DOI] [PubMed] [Google Scholar]
  15. Shidoji Y., Muto Y. Vitamin A transport in plasma of the non-mammalian vertebrates: isolation and partial characterization of piscine retinol-binding protein. J Lipid Res. 1977 Nov;18(6):679–691. [PubMed] [Google Scholar]

Articles from The EMBO Journal are provided here courtesy of Nature Publishing Group

RESOURCES