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. 1984 Sep;3(9):1997–2003. doi: 10.1002/j.1460-2075.1984.tb02081.x

Cosmid clones derived from both euchromatic and heterochromatic regions of the human Y chromosome.

J Wolfe, R P Erickson, P W Rigby, P N Goodfellow
PMCID: PMC557633  PMID: 6092051

Abstract

Clones containing sequences derived from the human Y chromosome have been isolated from cosmid libraries of a human-mouse hybrid cell line. These libraries were constructed in the new expression vectors Homer V and Homer VI. The collection of cosmids isolated is enriched for unique sequence DNA and only a few of the cosmids contain the tandemly repeated sequences which constitute a major portion of the Y chromosome. Three cosmids have been studied in detail. One cosmid shows extensive homology over at least 20 kb with the long arm of the X chromosome; this homology is outside the predicted homology region required for sex chromosome pairing. The other two clones contain unique sequences specific to the Y chromosome and both map to the heterochromatic region of the Y chromosome long arm.

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1997

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Selected References

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