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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Bioessays. 2017 Aug 9;39(9):10.1002/bies.201700073. doi: 10.1002/bies.201700073

Figure 2.

Figure 2

Meiotic Homologous Recombination. A: Meiotic HR is initiated by a programmed DSB. B: After resection and D-loop formation, intermediates can undergo SDSA to yield noncrossovers (NCOs). C: Crossover-designated intermediates in the Class I pathway are stabilized by pro-crossover complexes. D: Meiosis-specific endonucleases resolve dHJs, E: exclusively generating crossovers that are patterned along and among chromosomes and poised to promote disjunction at the end of meiosis. F: Alternatively, Class II intermediates are processed independent of pro-crossover complexes. G: Ligated dHJs can either be dissolved (not pictured) or cleaved in an unbiased manner, H: resulting in a 1:1 ratio of crossovers: noncrossovers. Brackets: Crossovers created exclusively through the Class II pathway can yield nondisjunction due to lack of crossover patterning [21]. Note: For simplicity, coordination of dHJ resolution between multiple nuclease subunits is not depicted.