Table 2.
Summary of eight regions (1MB or less) of significant SNP × FA interactions.
| Chr | Region | Sig SNPs | Biomarker | Location (bp) | Smallest Int. p-Value (rsid#:FA) | Genes Containing/Near SNPs | Previous Cardiometabolic Trait Evidence | EAF | Significant Without Interaction |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 239,809,739–239,811,390 | 2 | IL6 | 239,811,390 | 4.66 × 10–8 (rs16838623:ALA) | CHRM3, LOC105373225 | Hypertension [28] | 0.0222 | No |
| 2 | 163,855,536–164,056,447 | 4 | IL6 | 164,019,142 | 3.05 × 10–9 (rs12623456:DHA) | RPL7P61 | None | 0.0161 | No |
| 3 | 170,371,857–170,376,150 | 2 | MCP1 | 170,371,857 | 5.25 × 10–10 (rs7611820:OA) | RP11-373E16.1 CLDN11, LOC101928583, RPL28P1 | None | 0.0724 | No |
| 7 | 132,794,130–132,796,323 | 2 | ICAM | 132,796,323 | 1.00 × 10–8 (rs17424324:DPA_N6) | LOC105375512, CHCHD3 | None | 0.116 | No |
| 13 | 24,533,606 | 1 | TNF | 24,533,606 | 2.88 × 10–8 (rs17079653:OA) | LOC105370115, ANKRD20A19P, SPATA13 | None | 0.0233 | No |
| 14 | 49,803,164 | 1 | CRP | 49,803,164 | 2.93 × 10–8 (rs7160151:EDA) | LOC105378178 | None | 0.29 | No |
| 14 | 27,808,931–27,821,399 | 3 | CAM | 27,821,399 | 4.33 × 10–8 (rs17112580:OA) | CTD-3006G17.2, LOC728755 | None | 0.249 | No |
| 20 | 18,777,980–18,778,844 | 3 | CRP | 18,777,980 | 3.23 × 10–8 (rs3762220:OA) | LOC100270804, LINC00652, LOC107985399, EEF1A1P34, DTD1, C20orf78 | None | 0.0484 | No |
SNP, single nucleotide polymorphism; EAF, effect allele frequency. The genes that the significant interaction SNP is in or near (50 KB pair range on each side) is reported. Prior GWAS evidence is reported based on a search at http://www.ebi.ac.uk/gwas/. The column “Significant without interaction” indicates whether the SNP alone would have reached genome-wide significance if the FA interaction term was not in the model.