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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Pain. 2017 Sep;158(9):1733–1742. doi: 10.1097/j.pain.0000000000000965

Figure 5.

Figure 5

The beneficial effects of FTY720 on CIBP are IL-10-dependent. On post-surgical day 7 when mice exhibited sufficient CIBP behaviors (>5 flinches and >10 seconds guarding over a 2-minute period, days 10–14), mice were implanted with 7-day subcutaneous minipumps containing FTY720 (1 mg/kg/d). When measured on days 10 and 14, FTY720 micropump infusion reversed CIBP flinching (A) and guarding (B) behaviors. The ability of FTY720 to maintain reversal of CIBP behaviors was attenuated 1 h after intrathecal administration of IL-10 neutralizing antibody (αIL10; black arrow; n=8), but not IgG control (n=5). Data are expressed as mean ± SEM for (n) mice and analyzed by two-tailed, two-way ANOVA with Bonferroni comparisons. #P <0.05 vs. D10 or D14.