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. 2017 May 2;8(32):52913–52922. doi: 10.18632/oncotarget.17577

Figure 2. miR-106b re-sensitizes CCA cells to 5-FU.

Figure 2

(A and B) 5-FU-resistant M139 (A) and M214 (B) cells were transduced with miR-106b mimics and then treated with different dose of 5-FU and the percentage of cell survival was examined by MTT assays. C and D. The apoptotic rate of M139 (C) and M214 (D) cells, which were transduced with miR-106b mimics and then treated with 40 μM 5-FU for 36 h, were examined by flow cytometry. (E and F) Colony formation assay showed the numbers of colonies of M139 (E) and M214 (F) cells transduced with miR-106b and then treated with 40 μM 5-FU. (G and H) Tumor volume of subcutaneous xenografts, which were inoculated with M139 (G) or M214 (H) CCA cells, were measured. All data represent the means ± SEM of three independent experiments. * represents p<0.05, ** represents p<0.01, *** represents p<0.001.