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. Author manuscript; available in PMC: 2018 May 25.
Published in final edited form as: Oncogene. 2016 Dec 19;36(21):3015–3024. doi: 10.1038/onc.2016.455

Figure 5. PAX2 is a direct transcriptional target of wild-type p53 and mutant p53 represses the PAX2 promoter in MOE cells.

Figure 5

A) Wild-type p53 activates whereas p53mut represses PAX2 transcriptional promoter activation as measured by luciferase assay. B) Chromatin Immunoprecipitation (ChIP) analysis revealed that wild-type p53 enhanced whereas p53mut significantly reduced p53 occupancy on the PAX2 promoter. Statistical differences (p≤0.05) are between groups labeled a and b. ChIP analysis demonstrates wild-type p53 occupancy on C) Non-target control and D) MDM2, mutant p53 occupancy on the E) ATF promoter.