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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Science. 2017 Aug 17;357(6354):932–935. doi: 10.1126/science.aam9046

Fig. 1. Chromosome loss through iPSC reprogramming of SCT fibroblasts.

Fig. 1

(A) Experimental scheme to generate XXY, XYY, XY and XX iPSCs. 2i: inhibitors of GSK3ß and Mek1/2. LIF: leukemia inhibitory factor. (B-D) Slx (green) and Sly (magenta) DNA-FISH of (B) fibroblasts and (C, D) P2 iPSCs from XXY and XYY mice (n = 50 cells). Scale bars: 5 µm. (E) P2 iPSC sex chromosome complements. Each bar represents an iPSC line and the percentage of cells exhibiting each complement (n = 50 cells per line). Numbers in brackets show number of iPSC lines examined. Data for two animals combined.