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(A) A schematic of human IgG1. (B) The structure of CH3 domains of wild-type Fc (PDB: 3AVE). Key residues involved in CH3-CH3 interface are showed as sticks. Green, CH3A; cyan, CH3B. (C) Fc heterodimer engineering based on the knob-hole strategy (KiH). (D) Knob (A) and hole (B) chain formation was analyzed by non-reducing SDS-PAGE. The yield of Fc heterodimer was assessed by densitometry analysis and shown in C.
