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. 2017 May 3;8(31):51970–51985. doi: 10.18632/oncotarget.17583

Figure 2. CMA substrate proteins in cancer: the acetylated PKM2 displays a stronger interaction with HSC70.

Figure 2

Phosphorylation translocates Rnd3 from membrane to cytosol and promotes Rnd3 interaction with CMA. Unphosphorylated PED binds HSC70 and degradation by CMA. However, phosphorylated PED binds to HSC70 at a low level (dotted line). Misfolded N-CoR is associated with HSC70 and degraded through the CMA. The degradation of mutant TP53 is mediated by the CMA and the degradation of TP53 through macroautophagy.