Table 3. Results of subgroup analysis for ADPIOQ rs2241766 polymorphisms and CAD in type 2 diabetic patients.
| G VS T | GG+GT VS TT | GG VS GT+TT | GT VS TT | GG VS TT | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Study group | Study numbers | OR[95%CI] | I2(%)/Ph | OR[95%CI] | I2/Ph | OR[95%CI] | I2/Ph | OR[95%CI] | I2/Ph | OR[95%CI] | I2/Ph |
| Total | 10 | 1.18[0.89,1.56] | 80/0.000 | 1.11[0.88,1.39] | 68/0.000 | 1.21[0.56,2.61] | 81/0.000 | 1.14[0.98,1.32] | 52/0.030 | 1.33[0.69,2.55] | 72/0.000 |
| Enthicity | |||||||||||
| Caucasian | 8 | 1.32[1.15,1.51] | 78/0.000 | 1.30[0.97,1.73] | 64/0.007 | 1.57[1.13,2.18] | 79/0.000 | 1.26[1.06,1.49] | 32/0.17 | 1.74[1.23,2.46] | 72/0.000 |
| Mongoloid | 2 | 0.82[0.65,1.04] | 49/0.160 | 0.86[0.66,1.13] | 43/0.15 | 0.63[0.37,1.06] | 89/0.003 | 0.82[0.60,1.11] | 61/0.11 | 0.68[0.38,1.25] | 0/0.490 |
| Region | |||||||||||
| Eastern Asian | 2 | 0.82[0.65,1.04] | 49/0.160 | 0.89[0.73,1.07] | 43/0.15 | 0.63[0.37,1.06] | 89/0.003 | 0.82[0.60,1.11] | 61/0.110 | 0.67[0.37,1.21] | 0/0.49 |
| Western Asian | 4 | 1.66[1.34,2.06] | 85/0.000 | 1.51[1.16,1.96] | 76/0.005 | 3.27[2.04,5.22] | 77/0.004 | 1.21[0.91,1.62] | 40/0.17 | 2.97[1.10,8.03] | 65/0.040 |
| Southern Europe | 2 | 1.11[0.91,1.36] | 49/0.160 | 1.24[0.98,1.56] | 64/0.10 | 0.53[0.28,1.00] | 0/0.790 | 1.32[1.04,1.68] | 66/0.09 | 0.65[0.34,1.23] | 0/0.85 |
| Northern Europe | 2 | 1.19[0.84,1.68] | 70/0.07 | 1.20[0.79,1.82] | 63/0.10 | 0.75[0.28,2.05] | 54/0.140 | 1.15[0.75,1.76] | 50/0.16 | 1.60[0.35,7.42] | 48/0.16 |
| Sample Size | |||||||||||
| More than 500 | 2 | 1.05[0.88,1.25] | 69/0.07 | 1.07[0.91,1.25] | 60/0.060 | 0.45[0.27,0.73] | 0/0.450 | 1.22[0.99,1.51] | 80/0.030 | 0.69[0.42,1.14] | 0/0.74 |
| less than 500 | 8 | 1.29[1.10,1.51] | 82/0.000 | 1.21[0.99,1.46] | 73/0.000 | 2.10[1.47,3.00] | 75/0.000 | 1.06[0.87,1.31] | 45/0.080 | 2.07[1.41,3.04] | 69/0.002 |
| Genotyping Method | |||||||||||
| PCR-RFLP | 4 | 1.04[0.58,1.87] | 85/0.000 | 1.12[0.85,1.47] | 78/0.003 | 2.05[1.23,3.39] | 32/0.22 | 0.99[0.74,1.33] | 62/0.050 | 1.96[1.15,3.32] | 74/0.008 |
| PCR-HRM | 2 | 1.71[0.45,6.59] | 95/0.000 | 1.15[0.87,1.53] | 91/0.000 | 1.33[0.86,2.05] | 97/0.000 | 1.04[0.77,1.41] | 67/0.080 | 1.55[0.95,2.54] | 92/0.000 |
| PCR | 3 | 1.06[0.70,1.61] | 58/0.09 | 1.05[0.77,1.43] | 46/0.160 | 0.60[0.29,1.26] | 21/0.28 | 1.04[0.75,1.43] | 20/0.290 | 1.03[0.50,2.16] | 29/0.24 |
| Taqman | 1 | 1.21[0.96,1.52] | # | 1.13[0.95,1.36] | 65/0.060 | 0.57[0.26,1.24] | # | 1.49[1.13,1.96] | # | 0.62[0.28,1.37] | # |
Abbreviations: CI, confidence interval; OR, odds ratio; Ph, P value for heterogeneity from Q-test; I2, the proportion of the total variation across studies due to heterogeneity.
#No heterogeneity was observed for only one study.
Significant results are marked in bold.