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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Virology. 2017 Mar 27;506:84–91. doi: 10.1016/j.virol.2017.03.011

Figure 2. Proposed reaction mechanism.

Figure 2

The catalytic residue Glu 363 is proposed to accept a proton from the epsilon amino group of reactant Lys 169, rendering Lys 169 a good nucleophile that attacks the gamma carbon of the crosslinking partner, Asn 356. The proton transfer from Lys 169 to Glu 363 is proposed to be facilitated by a hydrophobic environment around the reaction site, of which a crucial component is supplied by Val 163.