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. 2017 Aug 11;9(9):1189–1203. doi: 10.2217/epi-2017-0052

Figure 5. . TP53 methylation across generations.

Figure 5. 

TP53 methylation in offspring was compared with those without a father or grandfather with alcohol dependence, with those with either a father or grandfather and those having both. Statistical analysis controlled for age at DNA collection, the mothers’ prenatal use of substances and the offspring’s personal use up to the time of DNA collection. Hypermethylation of CpG sites is seen in association with increased familial AD across generations (p = 0.0068). This hypermethylation suggests lesser expression of the tumor suppressor gene.

AD: Alcohol dependence.