Figure 2.

Comparison of proteins encoded by Iowa, Danish, and zebrafish GREB1L mutants. The human, mouse, and fish variants (position indicated in human protein) encode proteins that are altered in the conserved c-terminus of the protein. L1793R, Iowa protein; G1870FS, Danish protein; predicted glycosyltransferase domain indicated by green lettering (Iyer et al. 2013). Iowa L–R mutation indicated in red lettering, which was recapitulated in two out of three mouse mutants along with deletion of the following Q residue (see Figure S3 in File S1); Danish frameshift amino acids indicated in blue lettering; zebrafish W to STOP mutation indicated by purple W residue. Conserved c-terminus indicated by boxed region, with asterisks denoting amino acids conserved between GREB1 and GREB1L paralogs.