Skip to main content
. Author manuscript; available in PMC: 2017 Sep 7.
Published in final edited form as: Science. 2014 Nov 14;346(6211):1256442. doi: 10.1126/science.1256442

Figure 2. PRDM9-defined hotspots are found in the human PARs.

Figure 2

Overview of ~1 Mb regions on chromosome X overlapping the (A) PAR1 and (B) PAR2 pseudoautosomal boundaries (PABs). Normalized ssDNA coverage is shown as fragments per Kb per million (FPKM), smoothed using a sliding window (window: 1 Kb; step: 0.1 Kb). The baseline of the y-axes is 0 FPKM. Coverage is shown for the AA1, AA2, AB and AC individuals. Red and green bars depict PRDM9A-defined and PRDM9C-defined hotspots, respectively. Close up of a (C) 330 Kb region of the PAR1 and (D) the entire ~330 Kb PAR2 illustrating the presence of PRDM9C-defined hotspots (highlighted by grey bars) in both PARs.