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. 2017 Jul 15;8(33):55405–55421. doi: 10.18632/oncotarget.19265

Figure 4. The mRNA expression of genes associated with Notch signaling in BMMSCs from MM patients.

Figure 4

Real-time PCR was conducted to detect the level of genes involved in Notch signaling pathway. It was shown that mRNA expression of these genes, including Notch receptors Notch1 and Notch2, Notch ligands Jagged-1 and Deltalike-1, and Notch signaling downstream Hey-1, Hey-2, Hes-1, Hes-5 and Hey-L was obviously heightened in BMMSCs from MM patients (n=24) compared to that from healthy controls (n=10). The level of these genes was much more higher in BMMSCs from MM-B (n=10) as compared to MM-NB(n=14). All values are expressed as means ± SD. *p < 0.05, **p < 0.01.