Table 17. Summary of HIEPC-related procedures in different PC institutions or countries (published researches).

Country /No. Institutions	Major Institutions	No. patients	Mode	HIPEC-MMC alone	HIPEC-MMC+DDP	HIPEC-L-OHP alone	HIPEC-other	Temperature (°C)	Duration (min)
Spain, 6	M. D. Anderson Cancer Center [29, 71]
	Subtotal/Median/Range	?	O/C	Y		Y		40-43	30-120
	San Jose Hospital [29, 71]
	Subtotal/Median/Range	?	O/C	Y		Y		40-43	30-120
	Hospital Infanta Cristina [71]	?	O/C	Y		Y	others	40-43	30-120
	Hospital Santiago Apostol [13]	25	O/C	Y	Y	Y	MMC+CPT-11, 5-FU	40-43	30-90
Subtotal		>25	O/C	Y		Y	MMC+CPT-11, 5-FU	41.5 (40-43)	90 (30-120) /30
Canada, 2	University of Calgary [56, 66, 68, 73]
	Subtotal/Median/Range	375	O	12-15 mg		400 mg/m2		41.5 (40-42)	60
	Maisonneuve-Rosemont Hospital, University of Montreal [14, 38, 53]
	Subtotal/Median/Range	>40	O	30-50 mg/m2	30-50 mg/m2 + 50-100 mg/m2	360-460 mg/m2	L-OHP (360-460 mg/m2) + CPT-11 (100-200 mg/m2)	41.5 (41-42.5) /43 (42-43)	90 (60-120) /30 or 60
Subtotal		>415	O	12-15 mg /30-50 mg/m2	30-50 mg/m2 + 50-100 mg/m2	360-460 mg/m2	L-OHP + CPT-11	41.5 (41-42.5) /43 (42-43)	60 or 90 (60-120) /30 or 60
Greece, 2	Metaxa Cancer Memorial Hospital [29, 71]
	Subtotal/Median/Range	?	O/C	Y		Y		40-43	30-120
	Didimotichon General Hospital [13]	25	O/C	Y	Y	Y	MMC+CPT-11, 5-FU	40-43	30-90
Subtotal		>25	O/C	Y	Y	Y	MMC+CPT-11, 5-FU	41.5 (40-43)	30-90
Australia, 1	St. George Hospital [15, 26, 29, 34, 41, 45, 64, 72, 81, 90, 91]
Subtotal		>618	O	10-12.5 mg/m2		350 mg/m2		42	90 or 30

Note: C: closed abdomen technique for HIPEC; O: open abdomen technique for HIPEC; Y: yes; MMC: mitomycin C; DDP: cisplatin; 5-FU: fluorouracil; L-OHP: oxaliplatin; CPT-11: irinotecan