Figure 3. Diffusion changes associated with cognitive changes across 1 year in multiple linear regression analysis adjusted for age, sex, education, and baseline general cognitive performance.

Areas showing decrease in fractional anisotropy and increase in mean diffusivity are overlaid to canonical T1-weighted images. Colors refer to t values of significant diffusion tensor imaging changes (one-tailed p < 0.05 after correction for multiple comparison within each cluster, cluster size ≥10,000) on a scale of 1.7 (red) to 5 (yellow).