Table 4. Association between IL1 polymorphisms genotypes and RCC risk under different genotypic models.
| Model | Genotype | control | case | OR (95% CI) | P-value | |
|---|---|---|---|---|---|---|
| rs3783550 | Codominant | G/G | 206 (44.5%) | 106 (36.5%) | 1 | |
| G/T | 212 (45.8%) | 144 (49.7%) | 1.32 (0.96-1.81) | 0.053 | ||
| T/T | 45 (9.7%) | 40 (13.8%) | 1.73 (1.06-2.81) | |||
| Dominant | G/G | 206 (44.5%) | 106 (36.5%) | 1 | 0.031* | |
| G/T-T/T | 257 (55.5%) | 184 (63.5%) | 1.39 (1.03-1.88) | |||
| Recessive | G/G-G/T | 418 (90.3%) | 250 (86.2%) | 1 | 0.089 | |
| T/T | 45 (9.7%) | 40 (13.8%) | 1.49 (0.94-2.34) | |||
| Log-additive | --- | --- | --- | 1.32 (1.05-1.64) | 0.015* | |
| rs3783546 | Codominant | G/G | 206 (44.7%) | 106 (36.4%) | 1 | 0.040* |
| G/C | 210 (45.5%) | 144 (49.5%) | 1.33 (0.97-1.83) | |||
| C/C | 45 (9.8%) | 41 (14.1%) | 1.77 (1.09-2.87) | |||
| Dominant | G/G | 206 (44.7%) | 106 (36.4%) | 1 | 0.025* | |
| G/C-C/C | 255 (55.3%) | 185 (63.6%) | 1.41 (1.04-1.91) | |||
| Recessive | G/G-G/C | 416 (90.2%) | 250 (85.9%) | 1 | 0.072 | |
| C/C | 45 (9.8%) | 41 (14.1%) | 1.52 (0.97-2.38) | |||
| Log-additive | --- | --- | --- | 1.33 (1.07-1.66) | 0.011* | |
| rs1609682 | CoDominant | G/G | 205 (44.4%) | 106 (36.4%) | 1 | 0.046* |
| G/T | 212 (45.9%) | 144 (49.5%) | 1.31 (0.96-1.80) | |||
| T/T | 45 (9.7%) | 41 (14.1%) | 1.76 (1.09-2.86) | |||
| Dominant | G/G | 205 (44.4%) | 106 (36.4%) | 1 | 0.031* | |
| G/T-T/T | 257 (55.6%) | 185 (63.6%) | 1.39 (1.03-1.88) | |||
| Recessive | G/G-G/T | 417 (90.3%) | 250 (85.9%) | 1 | 0.070 | |
| T/T | 45 (9.7%) | 41 (14.1%) | 1.52 (0.97-2.39) | |||
| Log-additive | --- | --- | --- | 1.32 (1.06-1.65) | 0.013* | |
| rs3783521 | CoDominant | A/A | 206 (44.5%) | 106 (36.4%) | 1 | 0.043* |
| G/A | 212 (45.8%) | 144 (49.5%) | 1.32 (0.96-1.81) | |||
| G/G | 45 (9.7%) | 41 (14.1%) | 1.77 (1.09-2.87) | |||
| Dominant | A/A | 206 (44.5%) | 106 (36.4%) | 1 | 0.028* | |
| G/A-G/G | 257 (55.5%) | 185 (63.6%) | 1.40 (1.04-1.89) | |||
| Recessive | A/A-G/A | 418 (90.3%) | 250 (85.9%) | 1 | 0.069 | |
| G/G | 45 (9.7%) | 41 (14.1%) | 1.52 (0.97-2.39) | |||
| Log-additive | --- | --- | --- | 1.33 (1.06-1.66) | 0.012* | |
| rs1143623 | CoDominant | C/C | 159 (34.6%) | 110 (37.9%) | 1 | 0.065 |
| C/G | 233 (50.6%) | 124 (42.8%) | 0.82 (0.59-1.16) | |||
| G/G | 68 (14.8%) | 56 (19.3%) | 1.38 (0.88-2.17) | |||
| Dominant | C/C | 159 (34.6%) | 110 (37.9%) | 1 | 0.720 | |
| C/G-G/G | 301 (65.4%) | 180 (62.1%) | 0.94 (0.69-1.30) | |||
| Recessive | C/C-C/G | 392 (85.2%) | 234 (80.7%) | 1 | 0.040* | |
| G/G | 68 (14.8%) | 56 (19.3%) | 1.54 (1.02-2.32) | |||
| Log-additive | --- | --- | --- | 1.10 (0.88-1.37) | 0.400 |