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. 2017 Apr 6;8(34):57327–57336. doi: 10.18632/oncotarget.16905

Figure 1. Overview of the CD73-adenosinergic pathway.

Figure 1

(A) Adenosine limiting cytotoxic activity of effective immune cells; (B) Adenosine enhancing immunosuppressive effects; (C) Adenosine inducing anomalous differentiation and weakening the function of antigen presenting cells; (D) CD73 promoting tumor cells proliferation, migration, angiogenesis, and chemoresistance. ADO: Adenosine, AMP: Adenosine Monophosphate, ATP: Adenosine Triphosphate, NK cells: Natural Killer Cells, MDSCs: Myeloid Derived Suppressor Cells, VEGF: Vascular Endothelial Growth Factor.